新型新生儿中药退黄洗液治疗葡萄糖-6-磷酸脱氢酶缺乏症新生儿黄疸临床疗效观察

Clinical effect of novel Chinese medicine of neonatal Tuihuang lotion on jaundice neonates with G-6PD deficiency

目的观察新型新生儿中药退黄洗液治疗红细胞葡萄糖-6-磷酸脱氢酶(G-6-PD)缺乏症新生儿黄疸的临床疗效。方法 60例G-6-PD缺乏症新生儿黄疸患儿,按随机数字表法分为观察组和对照组,每组30例。对照组给予常规治疗及蓝光治疗,观察组在对照组的基础上加用新型新生儿中药退黄洗液泡浴治疗,疗程3 d。比较两组患儿治疗前后血清胆红素值、经皮测胆红素值、光疗时间、光疗指数。结果治疗3 d后,两组患儿血清胆红素、经皮胆红素值水平均较治疗前下降,而观察组血清胆红素、经皮胆红素水平均低于对照组(P<0.05),光疗时间短于对照组(P<0.05),但两组光疗指数比较,差异无统计学意义(P>0.05)。结论在常规治疗的基础上联合新型新生儿中药退黄洗液治疗G-6-PD缺乏症新生儿黄疸疗效好。

Objective To observe the clinical effect of novel Chinese medicine of neonatal Tuihuang lotion on jaundice neonates with glucose-6-phosphate dehydrogenase （G-6-PD） deficiency. Methods A total of 60 jaundice neonates with G-6-PD deficiency were divided into observation group and control group according to the random number table, with 30 cases in each group. The control group was given routine therapy and blue light treatment, while the observation group was given bath therapy with novel Chinese medicine of neonatal Tuihuang lotion besides the therapy performed in the control group. The treatment lasted for 3 days in both groups. The levels of serum and transcutaneous bilirubin as well as the duration and indicator of phototherapy before and after treatment were compared between the two groups. Results After 3 days of treatment,the levels of serum and transcutaneous bilirubin increased compared to those before treatment in the two groups, the levels in the observation group were lower than those in the control group （ P 〈 O. 05 ）, the duration of phototherapy in the observing group was lower than that in the control group （ P 〈 0.05 ）, and there was no significant difference in the indicator of phototherapy between the two groups （P 〉 0.05 ）. Conclusion Routine therapy combined with novel Chinese medicine of neonatal Tuihuang lotion can achieve better effect on jaundice neonates with G-6-PD defects.