视黄醇结合蛋白在糖尿病早期肾病诊断中的应用价值

Value of retinol binding protein in the early diagnosis of diabetic nephropathy

目的详细探讨视黄醇结合蛋白在糖尿病早期肾病诊断中的应用价值。方法本研究中收集2015年3月至11月期间我院住院内分泌科单纯糖尿病患者30例,糖尿病早期肾病患者30例,以及同期经健康检查排除糖尿病肾病体检者30例作为研究对象。对比观察三组受检对象在视黄醇结合蛋白、尿素以及血肌酐指标方面的检出水平,并对上述指标进行对比检验。结果三组受检对象尿素检出值对比均无明显差异(P>0.05),不具有统计学意义;糖尿病早期肾病组血肌酐检出值明显高于对照组与糖尿病无早期肾病组(P<0.05),具有统计学意义,对照组与糖尿病无早期肾病组血肌酐检出值对比无明显差异(P>0.05),不具有统计学意义;糖尿病早期肾病组视黄醇结合蛋白检出值明显高于对照组与糖尿病无早期肾病组(P<0.05),糖尿病无早期肾病组血肌酐检出值明显高于对照组(P>0.05),具有统计学意义。结论在对糖尿病早期肾病进行诊断中,检测分析视黄醇结合蛋白水平有积极意义,是糖尿病早期肾病诊断治疗的一项重要生化治疗,值得引起临床重视。

Objectives To investigate the detailed application of retinol binding protein in the early diagnosis of diabetic ne- phropathy. Methods In this study were collected in March 2015 - our hospital Endocrinology Endocrinology 30 patients with dia- betes alone,30 cases of early diabetic nephropathy,as well as health checks for the same period exclude diabetic subjects were 30 ca- ses for the study period November 2015. Comparative study in three groups of subjects＇retinol binding protein, urea, and serum creati- nine detection level indicators, and the positive rate of these indicators will be collated. Results The three groups of subjects＂ values were not significantly different contrast urea detected （ P 〉 0.05 ）, no statistically significant ; in diabetic nephropathy early detection of serum creatinine was significantly higher in non-diabetic nephropathy early group （ P 〈 0. 05 ）, with statistical significance, the control group, no early diabetic nephropathy serum creatinine values detected no significant difference in comparison （P 〉 0. 05 ）, no statistically significant ; early diabetic nephropathy retinol binding protein detection value significantly higher early diabetic nephropa- thy group without （P 〈 0. 05 ）, non-diabetic nephropathy early detection serum creatinine value was significantly higher （P 〉 0. 05 ）, with statistical significance. Conclusion The early diagnosis of diabetic nephropathy, the detection and analysis of retinol binding protein levels has a positive meaning, is an important biochemical treatment of diabetic nephropathy early diagnosis and treatment, deserves clinical attention.