疏血通联合奥扎格雷对急性脑卒中患者血清D-二聚体、C反应蛋白、同型半胱氨酸的影响分析

Effect of Shuxuetong Combined with Ozagrel on Serum D-dimer,C-reactive Protein and Homocysteine in Patients with Acute Stroke

目的分析急性脑卒中患者治疗中疏血通联合奥扎格雷对血清D-二聚体、C反应蛋白、同型半胱氨酸的影响。方法选取2001年4月至2015年11月于我院就诊的共93例急性脑卒中患者作为研究对象。根据随机数字表法将其分为研究组(n=52例)和对照组(n=41例)。研究组患者采用疏血通联合奥扎格雷治疗,而对照组患者仅采用奥扎格雷治疗,比较两组患者临床疗效以及治疗前后血清D-二聚体、C反应蛋白、同型半胱氨酸指标。结果研究组痊愈21例,有效27例,无效4例,总有效率为92.31%;对照组痊愈16例,有效17例,无效8例,总有效率为80.49%,研究组总有效率显著好于对照组,差异有显著性意义(χ~2=8.725,P<0.05)。两组患者治疗前D-D,hs-CRP和Hcy水平对比无显著性差异(P>0.05),治疗后两组患者各项指标均明显低于治疗前,且均有统计学差异(P<0.05),且研究组明显低于对照组(P<0.05)。结论疏血通具有多向调节、多靶点等神经保护和抗血栓作用,奥扎格雷可阻止血栓形成,抑制血小板聚集,两者联合可增强机体免疫力、抗氧化、抗炎、改善血液流变学,有效促进脑卒中患者的恢复。

Objectives To analyze the effects of Shuxuetong combined with ozagrel on serum D-dimer, C-reactive protein and ho- mocysteine in patients with acute stroke. Methods A total of 93 patients with acute stroke in our hospital from April 2001 to No- vember 2015 were selected as study subjects. The patients were divided into study group （n = 52） and control group （n = 41 ） ac- cording to the random number table method. The patients in the study group were treated with Shuxuetong combined with ozagrel. The patients in the control group were only treated with ozagrel. The clinical curative effect and the serum D-dimer, C-reactive protein and homocysteine index. Results In the study group,21 cases were cured,27 cases were effective and 4 cases were ineffective. The total effective rate was 92. 31%. In the control group, 16 cases were cured, 17 cases were effective ,8 cases were ineffective, the total effec- tive rate was 80. 49% In the control group, the difference was significant （X2 = 8. 725, P 〈 0. 05 ）. There was no significant difference in the levels of DD,hs-CRP and Hey between the two groups before treatment （P 〉 0. 05 ）. After treatment, the indexes of the two groups were significantly lower than those before treatment （ P 〈 0. 05 ）, And the study group was significantly lower than the control group （P 〈 0. 05 ）. Conclusion Shuxuetong has many neuroprotective and antithrombotic effects, such as mtdti-directional regulation, multi-target and so on. Ozagrel can prevent thrombosis and inhibit platelet aggregation. The combination of the two can enhance immunity, anti-oxidation and anti-inflammation. Rheology, effectively promote the recovery of stroke patients.