摘要
目的探讨X连锁凋亡抑制蛋白(XIAP)表达水平对颅内肿瘤切除术预后状况的影响。方法选取于该院行颅内肿瘤切除术的颅内肿瘤患者69例为研究对象;随访患者2年,依据生存时间的不同将患者分为≤2年生存时间组(短生存时间组)和>2年生存时间组(长生存时间组);采用酶联免疫吸附试验、蛋白免疫印迹(Western Blot)分别测定和比较2组患者血清、肿瘤和癌旁组织中XIAP的表达水平。结果短生存时间组患者血清中XIAP水平为(82.56±16.76)ng/L,显著高于长生存时间组的(46.21±8.59)ng/L,差异有统计学意义(P<0.05);长生存时间组患者肿瘤组织中XIAP蛋白表达水平显著低于短生存时间组,差异有统计学意义(P<0.05);2组患者XIAP蛋白表达水平均显著高于癌旁组织,差异有统计学意义(P<0.05);2组患者癌旁组织XIAP蛋白表达水平比较,差异无统计学意义(P>0.05);2组患者XIAP水平在不同性别、年龄、肿瘤类型之间比较,差异均无统计学意义(P>0.05);肿瘤直径>5cm者的XIAP水平均高于≤5cm者,差异有统计学意义(P<0.05)。结论 XIAP表达水平越低的患者,颅内肿瘤切除术预后越好,患者生存时间越长。
Objective To investigate the effect of X-linked inhibitor of apoptosis protein(XIAP)expression on the prognosis after resection operation in the patients with intracranial tumor.Methods Sixty-nine cases of intracranial tumor treated with tumor resection in our hospital were selected as the research subjects;the patients were followed up for 2years and divided into the survival time less than 2years group(short survival time group)and survival time more than 2years group(long survival time group)according to the survival time;the expression of XIAP in serum,tumor and adjacent tissues were measured by using enzyme-linked immunosorbent assay and Western blot and compared between the two groups.Results The serum XIAP level in the short survival time group was(82.56±16.76)ng/L,which was significantly higher than(46.21±8.59)ng/L in the long survival time group,the difference was statistically significant(P〈0.05);the XIAP protein expression level of tumor tissue in the long survival time group was significantly lower than that in the short survival time group,the difference was statistically significant(P〈0.05);moreover,the XIAP protein expressions level in the two groups was significantly higher than that in the adjacent tissues,the difference was statistically significant(P〈0.05);there was no statistically significant difference in the XIAP protein expression of the adjacent tissues between the two groups(P〉0.05);no statistically significant difference was observed in the XIAP level among different genders,ages and tumor types,the difference was statistically significant(P〉0.05);however,the XIAP level in the patients with the tumor diameter more than 5 cm was higher than that in the patients with tumor diameter less than 5 cm(P〈0.05).Conclusion The lower the level of XIAP expression,the better the prognosis in the patients treated with intracranial tumor resection,and the longer the survival time of patients.
出处
《检验医学与临床》
CAS
2017年第8期1065-1067,共3页
Laboratory Medicine and Clinic
基金
重庆市卫生与计划生育委员会科研资助项目(2016MSXM17)
关键词
X连锁凋亡抑制蛋白
颅内肿瘤切除术
预后
X-linked inhibitor of apoptosis protein
intracranial tumor resection
prognosis