颈动脉内膜中膜厚度与臂踝脉搏波传导速度的相关性研究

Correlation between carotid intima-media thickness and brachial-ankle pulse wave velocity

目的研究颈动脉内膜中膜厚度(CIMT)与臂踝脉搏波传导速度(baPWV)的相关性,分析主要影响因素。方法以健康体检者550例为研究人群,检测记录年龄、性别、身高、体质量、血压等基本信息,检测空腹血糖(FBG)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)等生化指标;采用动脉硬化检测仪检测baPWV、颈动脉超声测量CIMT,研究baPWV及CIMT的主要影响因素。以baPWV<1 400cm/s和baPWV≥1 400cm/s为标准分组比较各组CIMT值;再将CIMT值以CIMT<1mm、1mm≤CIMT<1.5mm、CIMT≥1.5mm为标准分组,比较各组baPWV值;线性回归比较CIMT和baPWV的相关性。结果 CIMT受性别、年龄、腰围、收缩压、LDL、踝臂指数(ABI)影响,差异有统计学意义(P<0.05)。baPWV受性别、体质量、年龄、腰围、收缩压、舒张压影响,差异有统计学意义(P<0.05)。baPWV与CIMT有显著相关性,差异有统计学意义(P<0.05)。结论 CIMT和baPWV呈线性关系。CIMT早期增厚期就已经有大动脉的动脉僵硬度改变,应在CIMT早期增厚期进行干预而非只重视斑块期的治疗。

Objective To explore the correlation between the carotid intima-media thickness（CIMT）and brachial-ankle pulse wave velocity（baPWV）and their main influencing factors.Methods A total of 545 individuals undergoing the healthy physical examination were taken as the research subjects.The basic information such as age,gender,height,weight and blood pressure（BP）were detected and recorded,fasting blood glucose（FBG）,total cholesterol（TC）,total triglyceride（TG）,low-density lipoprotein（LDL）and high-density lipoprotein（HDL）were detected.baPWV was detected by using the arterial sclerosis detection device,CIMT was measured by using the carotid ultrasonography technology.The main influencing factors of baPWV and CIMT were studied.The subjects were divided into different groups with baPWV1 400cm/s and baPWV≥1 400cm/s as the standards,the CIMT values were compared among groups;then with the CIMT1mm,1mm≤CIMT1.5mm and CIMT≥1.5mm as the standards,the baPWV values were compared among groups.The correlation between CIMT and baPWV was compared by the linear regression.Results CIMT was influenced by gender,age,waist circumference,systolic pressure,LDL and ABI,the difference was statistically significant（P〈0.05）.Meanwhile,baPWV was affected by gender,weight,age,waist circumference,systolic pressure and diastolic pressure,the difference was statistically significant（P〈0.05）,there was a significant correlation between baPWV and CIMT,the difference was statistically significant（P〈0.05）.Conclusion The linear correlation exists between CIMT and baPWV.Early thickening stage of CIMT already has the arterial stiffness change of large artery,it is necessary to conduct intervention at the early thickening stage of CIMT rather than only pay attention to plaque treatment.