内镜下微创保胆手术在胆囊良性病变中的应用价值及对患者CCK水平的影响

Application value of endoscopic minimally invasive gallbladder surgeryin benign gallbladder lesions andits influence on cholecystokinin level

目的探讨内镜下微创保胆手术在胆囊良性病变中的应用价值及对患者胆囊收缩素(CCK)水平的影响。方法回顾分析2014年2月至2016年2月该院收治的实施内镜下微创保胆手术的胆囊良性病变患者87例,观察患者治疗前后血脂水平、血瘦素(Leptin)与CCK水平、胆囊收缩功能、胆总管宽度及脂肪泻发生率变化情况。结果与治疗前比较,治疗后血清总胆固醇(TC)、低密度脂蛋白(LDL)、三酰甘油(TG)水平、胆总管宽度、脂肪泻发生率比较,差异无统计学意义(P>0.05),而高密度脂蛋白(HDL)、Leptin、CCK、最小剩余容积显著降低,差异有统计学意义(P<0.05),胆囊容积、胆囊收缩指数显著上升,差异有统计学意义(P<0.05)。结论内镜下微创保胆手术治疗胆囊良性病变安全可靠,可有效降低CCK水平,保留完整的胆囊功能。

Objective To investigate the application value of endoscopic minimally invasive gallbladder surgery in benign gallbladder lesions and its influence on cholecystokinin（CCK）level.Methods Eighty seven cases of benign gallbladder lesions treated by endoscopic minimally invasive gallbladder surgery in the hospital from February 2014 to February 2016 were retrospectively analyzed.The levels of blood lipids,leptin and CCK,gallbladder contraction function,width of the common bile duct and incidence rate of steatorrhea befioore and after treatment were observed in the two groups.Results The levels of serum TC,LDL and TG,width of the common bile duct and incidence rate of steatorrhea had no statistical difference between before and after treatment（P〉0.05）;while the levels of HDL,leptin and CCK,and minimum residual volume were significantly decreased compared with before treatment,the difference was statistically significant（P〈0.05）,while the gallbladder volume and gallbladder contraction index were significantly increased,the difference was statistically significant（P〈0.05）.Conclusion Endoscopic minimally invasive gallbladder surgery in treating benign gallbladder lesions is safe and reliable,can effectively reduce the CCK level and keeps the gallbladder intact function.