摘要
目的探究特异AT序列结合蛋白1(SATB1)和E-钙黏蛋白(E-cad)在乳腺癌中的表达及其临床意义。方法采用免疫组织化学SP法检测125例乳腺癌组织和47例癌旁组织中SATB1和E-cad的表达,并对两者的相关性表达与患者临床病理特征进行分析。结果 SATB1蛋白在乳腺癌组织中阳性率为73.6%,在癌旁组织中阳性表达率为10.6%,差异有统计学意义(P<0.05);E-cad在乳腺癌组织中的阳性表达率为57.6%,在癌旁组织中的阳性表达率为91.5%,差异有统计学意义(P<0.05);乳腺癌组织中SATB1和E-cad的表达与患者肿瘤大小、组织学分级、淋巴结转移、TNM分期和雌激素受体(ER)的表达均存在显著相关性,差异有统计学意义(P<0.05);乳腺癌组织中SATB1和E-cad的表达与患者的年龄、绝经与否、孕激素受体(PR)和人类表皮生长因子受体2(HER-2)的表达差异无统计学意义(P>0.05);在乳腺癌组织中SATB1和E-cad的表达呈负相关(r=-0.582,P<0.05)。结论 SATB1和E-cad在乳腺癌的发生发展中起重要作用,两者的联合检测对临床判断乳腺癌患者的病情发生及预后有重要意义。
Objective To investigate the expressions of SATB1 and E-cad in breast cancer and their clinical significance. Methods The expressions of SATB1 and E-cad were detected by immunohistochemical SP method in 125 cases of breast cancer tis- sues and 47 cases of adjacent non-cancerous tissues. Their correlation expression of SATB1 and E-cad and clinicopathological fea- tures were analyzed. Results The positive rate of SATB1 protein in breast cancer tissue was 73.6%, and which in adjacent non-cancerous tissues was 10.6 %, the difference was statistically significant（P〈0.05）. The positive expression rate of E-cad in breast cancer tissue was 57.6 %, and which in adjacent non-cancerous tissues was 91.5 %, the differenee was statistically significant（P〈0.05）. The expression of SATB1 and E-cad in breast cancer tissue was correlated with tumor size, histological grade, lymph node metastasis,TNM stage and ER expression,the difference was statistically significant（P〈0.05）, but there was no statistically sig- nificant correlation with age,menopause, PR and HER-2 expression（P〉0.05）. In breast cancer tissues, SATB1 and HER-2 expres- sion showed the negative correlation（r= -0. 582,P〈0.05）. Conclusion SATB1 and E-cad proteins play an important role in the occurrence and progression of breast cancer. Their combined detection has an important significance for the clinical judgment the oc- currence and prognosis of breast cancer.
出处
《检验医学与临床》
CAS
2017年第8期1116-1118,共3页
Laboratory Medicine and Clinic
