鼻内镜手术配合术后氟康唑冲洗对上颌窦真菌球型鼻窦炎患者疗效及其生命质量的影响

Clinical efficacy of nasal endoscopic sinus surgery cooperated by postoperative fluconazole flushing in treating maxillary sinus fungal ball sinusitis and its influence on quality of life of patients

目的探讨鼻内镜手术配合术后氟康唑冲洗对上颌窦真菌球型鼻窦炎患者的疗效及其生命质量的影响。方法选取2007年6月至2015年9月间该院诊治的上颌窦真菌球型鼻窦炎患者66例为研究对象,根据治疗方案的不同,将患者随机分为单独鼻内镜手术组(单独组)和鼻内镜手术联合术后氟康唑冲洗治疗组(联合组),每组各33例。分别比较2组患者的临床疗效,并采用SF-36量表评估2组患者的生命质量变化。结果单独组患者的治疗有效率为90.91%(30/33),略著低于联合组的96.97%(32/33),2组间比较差异无统计学意义(P>0.05);2组患者的不良反应发生率和复发率比较差异无统计学意义(P>0.05);术后6个月,2组患者SF-36各项评分值均显著升高,差异有统计学意义(P<0.05);与单独组比较,联合组患者的改善幅度更为显著,差异有统计学意义(P<0.05)。结论鼻内镜手术配合术后氟康唑冲洗治疗可在一定程度上提高上颌窦真菌球型鼻窦炎的治疗效果,并显著改善患者生命质量。

Objective To investigate the clinical efficacy of nasal endoscopic sinus surgery cooperated by fluconazole flushing in treating maxillary sinus fungal ball sinusitis and its influence on the quality of life of patients.Methods Sixty-six cases of maxillary sinus fungal ball sinusitis in the hospital from June 2007 to September 2015 were selected as the research subjects and randomly divided into the single nasal endoscopic surgery group（single group）and nasal endoscopic surgery combined with postoperative fluconazole flushing treatment group（combined group）according to the different treatments,33 cases in each group.The clinical efficacies were compared between the two groups,and the SF-36 scale wase used to assess the quality of life in the two groups.Results The effective rate in the single group was 90.91%（30/33）,which was slightly lower than 96.97%（32/33）in the combined group without statistical difference（P〈0.05）;there was also no statistically significant difference in the incidence rate of adverse reactions and recurrence rate between the two groups（P〈0.05）;at postoperative 6months,the scores of various SF-36 scale indexes were significantly increased,the difference was statistically significant（P〈0.05）;compared with the single group,the improvement amplitude in the combined group was more significant,the difference was statistically significant（P〈0.05）.Conclusion Nasal endoscopic surgery cooperated by postoperative fluconazole flusing treatment can improve the treatment effect of maxillary sinus fungal ball sinusitis in some extent,and significantly improve the quality of life of patients.