调强适形放射疗法同步顺铂及奈达铂方案对局部晚期鼻咽癌的疗效比较

Comparation of Clinical Efficacy of Intensity Modulated Radiation Therapy-Cis-platinum and Nedaplatin in Patients with Locally Advanced Nasopharyngeal Carcinoma

目的:比较调强适形放射疗法(Intensity modulated radiation therapy,IMRT)与顺铂及奈达铂方案对局部晚期鼻咽癌的临床疗效。方法:选取2015年1月~2016年1月收治的局部晚期鼻咽癌患者96例,分为观察组和对照组,每组48例;观察组给予IMRT与顺铂治疗,对照组给予IMRT与奈达铂治疗,比较治疗后两组总有效率、不良反应发生率。结果:观察组治疗后的总有效率为79.17%稍低于对照组的81.25%,经组间比较其差异无统计学意义(P>0.05),后者用药期间不良反应的发生率显著低于前者(P<0.05)。结论:与IMRT与顺铂治疗相比,采用IMRT与奈达铂治疗局部晚期鼻咽癌疗效相近,不良反应的发生率优于IMRT与顺铂疗法。

Objective：To investigate the clinical efficacy and safety of cisplatin or nedaplatin combined with Intensity Modulated Radiation Therapy （IMRT） in patients with locally advanced nasopharyngeal carcinoma. Method：96 patients with locally advanced nasopharyngeal carcinoma in our hospital from January 2015 to January 2016 were randomly divided into two groups （48 patients each group）. After induction chemotherapy, they were treated with IMRT and chemotherapy using cisplatin （trial group） or nedaplatin （control group）. The clinical efficacy and adverse reaction were performed to compare these two different treatment sehems. Result：The total effective rate of treatment was 79.17% in trial group using cisplatin and 81.25% in control group using nedaplatin with no significant difference （P〉 0.05）. The incidence rate of adverse reactions such as nausea and vomiti were lower in control group （P〈0.05）. Conclusion：Compared with using cisplatin, combining nedaplatin and IMRT has same efficacy and lower incidence rate of adverse reactions to treat patients with locally advanced nasopharyngeal carcinoma, which is worth popularizing and applying.