1例甲巯咪唑致严重粒细胞缺乏症及肝损害的诊治分析

Clinical analysis of a case of agranulocytosis and hepatic function damage induced by methimazole in hyperthyroidism patient

目的:对我院1例甲巯咪唑致甲亢患者严重粒细胞缺乏症及肝功能损害的诊治进行分析总结。方法:停用抗甲亢药物甲巯咪唑,及时给予升白细胞药物、保肝药物、激素等综合措施,病情稳定后予碘131治疗。结果:甲巯咪唑导致的粒细胞减少及肝损害可以有效治疗。结论:抗甲亢药物首次服用后,应短期内密切观察外周血白细胞计数及肝功能,及时防止严重粒细胞缺乏症及肝功能损害发生发展。

Objective ：To analysis and summary of the treatment for a case of agranulocytosis and hepatic function damage induced by methimazole （MMI） in hyperthyroidism patient. Methods：Discontinuation of methimazole as a antithyroid drug （ATD）,and adopted comprehensive measures to increase the white blood cell （WBC）and protect liver,then take ^131I treatment after the stable condition. Resuhs：Agranulocytosis and hepatic function damage induced by methimazole can be effectively treated.Conclusion：Initial treatment in antithyroid drug, we should closely observe the peripheral WBC and liver function, and timely control of the incidence of agranulocytosis and hepatic function damage.