促血管生成素-2和血管内皮生长因子在尖锐湿疣血管生成机制中的相关性研究

Relationship Between Angiopoietin-2 and Vascular Endothelial Growth Factor in the Pathogenesis of Condyloma Acuminatum

目的:探讨促血管生成素-2(Ang-2)和血管内皮生长因子(VEGF)在尖锐湿疣皮损组织及外周血中的表达,研究二者在尖锐湿疣发病中的作用和意义。方法:随机选择30例尖锐湿疣患者,应用免疫组织化学法检测皮损中Ang-2及VEGF蛋白的表达情况,双抗体夹心酶联免疫吸附法检测其外周血血清中Ang-2及VEGF的水平,并与20例正常人比较。结果:与对照组比较,尖锐湿疣银屑病患者皮损处的Ang-2和VEGF的表达明显增强(χ~2值分别为31.04、18.07,P<0.01),血清中Ang-2及VEGF水平明显升高(t值分别为3.16、5.56,P<0.05)。结论:尖锐湿疣中Ang-2和VEGF表达上调,可能促进血管形成,参与尖锐湿疣的发生和发展。

Objective：To investigate the effects of angiopoietin-2（Ang-2）and vascular endothelial growth factor（VEGF）expression in condyloma acuminatum tissues and peripheral blood,and the significance of the research two in the pathogenesis of condyloma acuminatum in rats.Methods：Randomly selected 30 cases of patients with condyloma acuminatum,the expression of Ang-2and VEGF protein detected by immunohistochemical method of double antibody sandwich enzyme-linked immunosorbent assay and Ang-2VEGF assay in peripheral blood serum level,and compared with 20 normal controls.Results：Compared with the control group,the expression of condyloma acuminatum lesions of patients with psoriasis Ang-2and VEGF obviously increased（χ^2 respectively.31.04,18.07,P,Ang-2and〈0.01）were significantly increased in serum VEGF levels（t=3.16,5.56,Pvalue〈0.05）.Conclusion：The expression of Ang-2and VEGF expression in condyloma acuminatum,may promote the formation of blood vessels in condyloma acuminatum and occurrence Development.