PMMA-硅胶夹持型人工角膜不同手术方式的动物实验研究

The Animal Experimental Study of Different Operation Methodsof PMMA-silicone-clamped Keratoprosthesis

目的探索更好的碱烧伤兔眼的人工角膜移植手术方式.方法使用2种不同的手术方式将改进的人工角膜植入2组碱烧伤兔眼(A组和B组),A组行人工角膜植入术,B组行人工角膜植入联合虹膜切除和前节玻切术,观察人工角膜术后结果.结果 A组平均在位时间为273.58 d,B组平均在位时间为374.42 d;A组手术后7眼出现高眼压的情况,而B组仅有1眼眼压增高.2组在位时间及高眼压的比较,差异有统计学意义(P<0.05).结论联合虹膜切除和前节玻切的人工角膜植入手术操作方式是一种更好的的手术方式.

Objective To search a better operation method for the keratoprosthesis transplantation in alkali-burned rabbit eyes. Methods The improved keratoprostheses were implanted into 2 groups （A and B） of alkali-burned rabbit eyes by using 2 different operation methods： in group A, the keratoprostheses were implanted singlely; in group B, the keratoprostheses were implanted combined with iridectomy and anterior vitrectomy. We evaluated the postoperative outcomes. Results The average retention time in group A was 273.58 days; In group B was 374.42 days. 7 eyes in group A had increased intraocular pressure postoperatively, while Only 1 eyes had increased intraocular pressure in group B. The difference between the two groups was statistically significant in the retention time and increased intraocular pressure. Conclusion The iridectomy-combined operation method （group B） is a better keratoprosthesis implantation method.