3种常用保肝药物治疗药物性肝损伤的临床效果对比

Comparison of Effects on Drug-induced Liver Injury Treated with three Common Liver Drugs

目的对3种常用保肝药物在药物性肝损伤患者中的治疗效果进行研究、比较.方法抽选66例药物性肝损伤患者,患者入院后随机分为甲组、乙组、丙组,每组22例,甲组患者采用多烯磷脂酰胆碱进行治疗,乙组患者采用还原型谷胱甘肽进行治疗,丙组采用硫普罗宁进行治疗,对3组患者治疗后的效果进行调查,同时收集患者治疗过程中不良反应发生率.结果甲组患者疗效评估有效率为68.2%,乙组为95.5%,丙组为63.6%,3组比较差异有统计学意义(P<0.05).甲组患者不良反应发生率为27.3%,乙组为4.5%,丙组为36.4%,3组比较差异有统计学意义(P<0.05).甲组患者肝功能恢复正常的时间平均为(27.3±5.2)d,乙组为(20.6±4.5)d,丙组为(25.8±5.1)d,3组比较存在明显差异(P<0.05).结论还原型谷胱甘肽在药物性肝损伤患者中具有更高的治疗效果和治疗安全性.

Objective To study and compare the curative effects of drug-induced liver injury treated with three common liver drugs. Methods Sixty-six cases of drug-induced liver injury patients were screened, and were randomly divided into Group A, B and C when admitted to the hospital, 22 cases in each group. The Group A was given polyene phosphatidylcholine therapy, Group B glutathione therapy, and group C tiopronin therapy. The curative effects of these three groups were investigated, and the adverse reactions incidences during the treatment were analyzed. Results The effective rate in Group S was 68.2%, Group B 95.5%, Group C 63.6% , with significant differences （P〈0.05） . The adverse reactions incidence in Group A was 27.3%, Group B 4.5%, Group C 36.4%, with significant differences （P〈0.05） . The average time of liver function returned to normal in Group A was （27.3 ± 5.2） days, Group B （20.6 ± 4.5） days, Group C （25.8 ± 5.1） days, with significant difference （ P 〈0.05） Conclusionn Glutathione has better treatment effects and safety in treatment of drug-induced liver injury.