中西医结合治疗小儿支气管哮喘慢性持续期的临床疗效及对免疫功能的影响

Clinical efficacy and influence on immune function of pediatric bronchial asthma in chronic persistent period treated with the combined therapy of Chinese and Western medicine

目的观察中西医结合治疗小儿支气管哮喘慢性持续期的临床疗效及对免疫功能的影响。方法将122例支气管哮喘慢性持续期患儿随机分为治疗组62例与对照组60例,对照组给予孟鲁司特钠咀嚼片治疗,治疗组在对照组治疗方法的基础上结合肃肺平肝养阴汤治疗。治疗4周后统计2组的临床疗效,治疗前、后肺功能指标和免疫功能指标水平的变化,不良反应发生情况。结果对照组总有效率为75.00%,治疗组为91.94%,2组比较差异有统计意义(P<0.05)。2组治疗前第1秒用力呼气容积(FEV_1)和用力肺活量(FVC)经统计学分析,差异均无统计意义(P>0.05);治疗后2组FEV_1和FVC均显著升高,与同组治疗前比较,差异均有统计意义(P<0.05),且治疗组升高幅度均大于对照组(P<0.05)。2组治疗前免疫球蛋白(Ig)A,IgM,IgE,IgG水平比较,差异均无统计意义(P>0.05);治疗后2组IgA,IgM水平均升高,IgE水平下降,与同组治疗前比较,差异均有统计意义(P<0.05),且治疗组改善幅度大于对照组(P<0.05)。IgG治疗前后差异无统计意义(P>0.05)。2组均未见不良反应情况发生。结论中西医结合治疗小儿支气管哮喘慢性持续期疗效显著,可显著改善患儿的免疫功能,且安全可靠,值得临床推广。

Objective To observe clinical efficacy and influence on immune function of pediatric chronic bronchial asthma in chronic persistent period treated with the combined therapy of Chinese and Western medicine. Methods 122 cases of children with bronchial asthma in chronic persistent period were randomly divided into therapy group（62 cases） and control group（60 cases）. The control group was treated with Montelukast Sodium Chewable Tablets,while the therapy group was given Sufei Pinggan Tang on the basis of the treatment of control group. After 4 days treatment,the clinical efficacy,untoward effect,some changes of lung function and immune function before and after treatment in two groups were observed. Results The total effective rate in therapy group（91.94%） was higher than that in control group（75.00%）,difference between two groups has statistical significance（P〈0.05）. Lung function indices of two groups,FEV_1 and FVC,had no significant difference before treatment（P〈0.05）. After treatment,FEV_1 and FVC were raised obviously than these before treatment with significant difference（P〈0.05）,and they were raised more highly in therapy group than in control group（P〈0.05）. After treatment,IgA and IgM increased while IgE dropped in two groups,there were significant differences comparing with that before treatment（P〈0.05）,and the improvement in therapy group was more than that in control group（P〈0.05）. Difference of IgG had no statistical significance（P〈0.05）. No untoward effect was observed in both groups. Conclusion The combined therapy of Chinese and Western medicine can treat children with bronchial asthma in chronic persistent period effectively,for it is secure to improve immune function,which is worthy of clinical promotion.