静脉溶栓治疗高龄急性脑梗死的临床效果

Clinical effect of intravenous thrombolysis treating senile acute cerebral infarction

目的探讨静脉溶栓治疗高龄急性脑梗死的临床效果。方法选取本院2014年10月~2016年10月收治的高龄急性脑梗死92例,根据随机数字表法将患者分为对照组和治疗组,每组46例。对照组采用常规抗血小板治疗方案进行治疗,治疗组采用重组组织型纤溶酶原激活剂静脉溶栓方案进行治疗。比较两组患者的脑神经功能恢复正常时间和用药治疗总时间、不良反应发生率、总有效率、治疗前后的神经功能缺损程度评分和Barthel评分。结果治疗组患者脑神经功能恢复正常时间和用药治疗总时间短于对照组,差异有统计学意义(P<0.05);治疗组的不良反应发生率为2.2%,低于对照组的19.6%(P<0.05);治疗组总有效率为91.3%,高于对照组的71.7%,组间差异有统计学意义(P<0.05);神经功能缺损程度评分和Barthel评分在药物治疗前后的改善幅度大于对照组,差异有统计学意义(P<0.05)。结论高龄急性脑梗死疾病患者采用静脉溶栓方式治疗,能够使神经功能在短时间内得到大幅度改善,降低不良反应发生率,提高治疗安全性和总有效率。

Objective To explore the clinical effect of intravenous thrombolysis treating senile acute cerebral infarction. Methods 92 senile acute cerebral infarction patients from October 2014 to October 2016 treated in our hospital were selecetd and divided into control group and treatment group according to random number table method,and each group had 46 cases.The control group was given general antiplatelet therapy,the treatment group was given intravenous thrombolysis with recombinant tissue plasm!nogen activator.The neurological function recovery time and the total treatment time,the incidence rate of adverse reactions,the total effective rate,neurological deficit score and Barthel score before and after treatment between two groups were compared.Results The neurological function recovery time and the total treatment time in treatment group were shorter than control group,and the difference was obvious （P〈0.05）.The incidence rate of adverse reaction in treatment group （2.2%） was lower than that was 19.6% in control group （P〈0.05）.The total effective rate of （91.3%） treatment group was higher than that was 71.7% in control group,and the difference was obvious between two groups （P〈0.05）.Before and after treatment,the improvement range of neurological deficit score and Barthel score were higher than control group,and the difference was significant （P〈0.05）.Conclusion intravenous tbrombolysis for senile acute cerebral infarction patients can make the nerve function to get a substantial improvement in a short time,reduce the possibility of adverse drug reactions and improve the safety and the total effective rate of treatment.