利脑心胶囊对小鼠实验性缺氧的保护作用

Effect of the capsule of Linaoxin on the expermiental hypoxia in mice

目的:观察利脑心胶囊对小鼠实验性缺氧的保护作用。方法:采用常压和低压缺氧条件下分别观察正常小鼠和利脑心胶囊用药小鼠的平均存活时间和心肌耗氧量。结果:利脑心胶囊3个剂量组用药均可使常压和低压缺氧条件下小鼠存活时间延长(P<0.05~P<0.01);常压密闭条件下1~5 min时段小鼠的累积时间心肌耗氧量用药组均能明显降低(P<0.01),各用药组间差异亦均有统计学意义(P<0.05~P<0.01)。对常压密闭条件下小鼠的每分钟净耗氧量用药组在1~2 min时段均显著降低(P<0.01),3~4 min时段用药组与正常组、用药组间均无统计学意义(P>0.05)。结论:利脑心胶囊能明显降低小鼠氧耗,保护缺氧心肌。

Objective ：To observe the protective effect of the capsule of Linaoxin on the experimental hypoxia in mice. Methods：The effect of the capsule of Linaoxin on the mean survival time and capacity for myocardial oxygen consumption under ordinary or low pressure in mice were observed. Results：Linaoxin capsules in three dosage groups could prolong the survival time of mice under the condition of low pressure and normobaric hypoxia（ 1 - 5 min periods） （ P 〈 0.05 - P 〈 0.01 ） ; the accumulating time, myocardial oxygen consumption of medication groups under the normal pressure closed condition were obviously reduced （ P 〈 0.01 ）, there was significant difference in medication groups（ P 〈 0. 05 -P 〈 0. 01 ） ;the minute net oxygen consumption of the mice in medication groups under the normal pressure closed condition （1 -2 rain periods） was obviously lowered （P 〈 0. 01 ）, there were no significant differences between the medication groups and the control group, significant differences could not be found in the medication groups （ P 〉 0. 05 ）. Conclusions：The capsule of Linaoxin could evidently reduced capacity for myocardial oxygen consumption and shows a protective role in the hypoxic myocardium in mice.