血尿酸水平与2型糖尿病患者下肢动脉病变的相关性研究

The correlation study between the serum uric acid level and lower extremity arterial disease in patients with type 2 diabetes mellitus

目的:探讨血尿酸(SUA)水平与2型糖尿病(T2DM)患者下肢动脉血管病变(LEAD)的相关性。方法:431例T2DM患者,根据SUA四分位数分为4组:Q1组,≤252μmol/L,108例;Q2组,253~323μmol/L,108例;Q3组,324~430μmol/L,107例;Q4组,≥431μmol/L,108例。采用动脉硬化检查装置/血压脉波检查装置测定踝肱指数(ABI)。记录一般资料,检测生化指标,研究SUA水平与T2DM患者LEAD的相关性。结果:Q1组与Q2组间LEAD发生率差异无统计学意义(P>0.05);与Q1组比较,Q3组、Q4组LEAD发生率均显著升高(P<0.01)。logistic回归分析显示,Q3组(OR:3.44,95%CI:1.90~6.20,P<0.01)、Q4组(OR:8.31,95%CI:4.50~15.35,P<0.01)LEAD发生率显著升高。结论:随着SUA水平升高,T2DM患者LEAD发生率增加;高SUA水平是T2DM患者LEAD的危险因素。

Objective：To explore the correlation between the serum uric acid（SUA） level and lower extrornity arterial disease （LEAD） in patients with type 2 diabetes （T2DM）mellitus. Methods：Four hundred and thirty-one patients with T2DM were divided into Q1 group（ 108 cases, SUA ≤252 μmol/L）, Q2 group（ 108 cases, SUA 〉 252 - 323 μmol/L）, Q3 group （ 107 cases, SUA 〉 324 - 430 μmol/L） and Q4 group（ 108 cases, SUA 〉 430μmo/L） according to the quartile of serum uric acid. The ankle braehial index（ABI） of all patients was determined using the arteriosclerosis/blood pressure pulse check device. The general data and biochemical index were recorded. The correlation between the SUA level and LEDA in patients with T2DM was investigated. Results： The difference of the LEAD incidence between Q1 group and Q2 group was not statistically significant（P 〉 0.05）. Compared with the Q1 group,the LEAD incidence in Q3 and Q4 groups significantly increased（P 〈0.01 ）. The logistic regression analysis showed that the LEAD incidence in Q3 group（ OR：3.44,95% CI： 1.90 - 6.20, P 〈 0.01 ） and Q4 group （ OR：8.31,95% CI：4.50 ～ 15.35, P 〈 0.01 ） significantly increased. Conclusions：With the increasing of the SUA level, the incidence of LEDA in T2DM patients increases. The high SUA level is a risk factor of LEAD in T2DM patients.