2型糖尿病合并周围神经病变患者心率减速力与心率变异性的相关性分析

Correlation analysis between heart rate deceleration force and heart rate variability in patients with type 2 diabetes complicated with peripheral neurpathy

目的:探讨2型糖尿病合并周围神经病变患者心率减速力(DC)与心率变异性(HRV)的相关性。方法:选择2型糖尿病患者100例,根据是否合并周围神经病变分为2型糖尿病组(DM组,n=42)和2型糖尿病周围神经病变组(DPN组,n=58),进行24 h动态心电图检查,观察DC和HRV相关时域指标之间的关系。结果:DPN组患者的DC及HRV各相关时域指标均明显低于DM组(P<0.01)。校正糖化血红蛋白等影响后,DPN组患者DC与HRV各相关时域指标(SDNN、RMSSD和PNN50)均呈正相关关系(P<0.01),DM组患者DC与HRV各相关时域指标亦均呈正相关关系(P<0.05~P<0.01)。结论:2型糖尿病周围神经病变患者DC及HRV降低明显,且DC与HRV密切相关。DC可定量评估2型糖尿病患者迷走神经张力,可作为早期诊断糖尿病自主神系统损害的敏感指标。

Objective： To explore the correlation between heart rate deceleration force （DC） and heart rate variability （HRV） in patients with type 2 diabetes complicated with peripheral neuropathy. Methods：One hundred patients with type 2 diabetes were divided into the type 2 diabetics group（ DM group ,42 cases） and type 2 diabetes peripheral neuropathy（ DPN group,58 cases）. All cases were detected using the 24 hours dynamic electrocardiogram, and the relationship between HRV and DC was analyzed. Results： The parameters of DC and HRV in DPN group were significantly lower than those in DM group（P 〈0.01 ）. After the effect of HbAc was corrected, the DC in DNP and DM group were positive correlation with the parameters of HRV （including SDNN, RMSSD and PNN50） （ P 〈 0.05 to P 〈 0.01 ）. Conclusions ： The DC and HRV in patients with type 2 diabetes complicated with peripheral neuropathy significantly decrease, and the DC is closely associated with HRV. DC can be used to quantitatively assess the vagal tone of patients with type 2 diabetes, which is a sensitive indicator in early diagnosis of diabetic autonomic system damage.