小儿EB病毒感染相关疾病临床研究

Clinical Study of EB Virus Infection in Children

目的对小儿EB病毒感染的相关疾病进行研究。方法选择我院在2015年1月-2016年12月收治的248例EB病毒感染的患儿作为本研究的研究对象,对所有患儿的临床资料进行回顾性分析,总结EB病毒感染的临床特点,特别是对于除了传染性单核细胞增多症以外的各种系统疾病。结果本研究有传染性单核细胞增多症患儿61例,除此之外还有支原体肺炎50例,重症肝炎32例,病毒性心肌炎30例,脓毒症12例,手足口病11例,血小板减少症11例,病毒性脑炎7例,疱疹性咽峡炎5例,急性扁桃体炎5例,川崎病4例,原发性肾病综合征4例,婴儿肝炎综合征3例,嗜血细胞综合征3例,血小板减少性紫癜2例,幼年特发性关节炎(全身型)2例,急性坏死性淋巴结炎2例,还有胚胎型横纹肌肉瘤、渗出性多形性红斑、骨嗜酸性肉芽肿和神经损伤各1例。传染性单核细胞增多症是EB病毒的主要感染性疾病,这种病情一般以幼儿期和学龄期的小儿为主,而且大多数都具有典型的临床症状,患儿的眼睑存在有浮肿,而且存在有鼻塞的情况,这是传单的重要临床特点。结论 EB病毒的感染和很多疾病都具有密切的关联,特别是对于传染性单核细胞增多症,这是导致该疾病发生的主要因素,临床上对于EB病毒需要进行积极的抗病毒治疗,只有这样才能达到较好的治疗效果。

Objective To study the related diseases of EB virus infection in children. Methods In our hospital from January 2015 to December 2016 were 248 cases of EB virus infection in children as the research object of this study, the clinical data of all patients were analyzed retrospectively, to summarize the clinical characteristics of EB infection, especially for infectious mononucleosis in addition to all kinds of disease outside the system. Results Children with infectious mononucleosis in 61 cases of this study, as well as in 50 cases of mycoplasma pneumonia, 32 cases of severe hepatitis, 30 cases of viral myocarditis, 12 cases of sepsis, 11 cases of HFMD, thrombocytopenia in 11 cases, 7 cases of viral encephalitis, 5 cases of herpangina, 5 cases of acute tonsillitis, 4 cases of Kawasaki disease, 4 cases of primary nephrotic syndrome, 3 cases of infantile hepatitis syndrome, 3 cases of hemophagocytic syndrome, 2 cases of juvenile idiopathic arthritis （general type）, 2 cases of acute necrotizing lymphadenitis, and 2 cases of embryonal rhabdomyosarcoma, exudative erythema multiforme, eosinophilic granuloma of bone and nerve injury in 1 case. Infectious mononucleosis was a major infectious disease virus EB, this disease was mainly in early childhood and school-age children, and most had typical clinical symptoms, patients had eyelid edema, and nasal congestion situation, this was an important clinical feature of leaflets. Conclusion EB infection and many diseases are closely related, especially for infectious mononucleosis, which are the main factors leading to the occurrence of disease, clinically for a group of viruses requires active antiviral treatment, the only way to achieve a good therapeutic effect.