硫酸镁治疗哮喘有效性和安全性探讨

Efficacy and Safety of Magnesium Sulfate in the Treatment of Asthma

目的观察联用硫酸镁注射液治疗重度支气管哮喘的疗效。方法92例哮喘急性发作患者随机分为两组,治疗组47例,对照组45例,对照组给予常规治疗方法,治疗组在此基础上加用硫酸镁注射液。观察两组患者治疗期间症状改善情况、血气分析、肺功能、细胞因子和不良反应指标。结果两组症状改善情况总有效率分别为93.61%和75.56%,治疗组疗效优于对照组(P<0.05)。治疗组患者血气分析、肺功能改善情况优于对照组。两组患者血清TGF-β1、TNF-α水平均显著减低,但两组间比较无差异。两组患者不良反应无差别。结论在常规治疗的基础上加用硫酸镁治疗哮喘安全有效。

Objective To learn the clinic effect and untoward effect of using magnesium sulfate on severe asthma. Methods 92 patients of Asthma weredivided into two groups randomly. The control group （n=45） used the common therapy, while the experimental group （n=47） added the therapy of magnesium sulfate.Then the clinic effect, blood gas analysis, lung function, cytokines and side effect of two groups were observed. Results The total effectiveness of the experimental group and the control group were 93.61%, 75.56%. The clinical effect rate of the experimental group was better than the control group, with statisticalsignificance （P〈0.05）. The blood gas analysis, lung function improvement of the treatment group were better than the control group. The serumTGF-β1, TNF-α levels of two groups were significantly reduced, but there were no significant difl＇erence between two groups. The side effect between two groups hadn＇t statistical significance. Conclusion The magnesium sulfate has excellent effect and is safety in tracting asthma.