妊娠早期子宫动脉的多普勒监测对子痫前期的预测价值

First Trimester Uterine Artery Doppler Predictive Value of Preeclampsia

提前识别孕妇患子痫前期的风险,可以降低孕产妇和胎儿的发病率和死亡率。子宫动脉多普勒频谱分析在妊娠中期预测子痫前期的研究已较广泛。利用妊娠早期子宫动脉多普勒来预测子痫前期成为了近年的研究热点。子宫动脉多普勒参数作为单独的标志物,其敏感度不高。妊娠早期子宫动脉多普勒参数(如搏动指数)与母体特征及相关生化标志物(如妊娠相关血浆蛋白A、胎盘生长因子)相结合,对早发型子痫前期的检测率高于90%。但结合生化标志物增加了成本,未来研究的方向是筛选最佳组合的预测模型来早期预测子痫前期。

Early recognition of the pregnant women with preeclampsia can reduce the risk of maternal and fetal morbidity and mortality. Uterine artery doppler waveform analysis for prediction of second trimester pregnancy preeclampsia markers have been widely studied. And the use of uterine artery doppler in first trimester pregnancy to predict preeclampsia become a research hotspot in recent years. Uterine artery doppler parameters as individual markers, its sensitivity is not high.First-trimester uterine artery doppler parameters（ such as pulse index） combined with the maternal characteristics and biochemical markers（such as： pregnancy associated plasma protein A and placental growth factor） can achieve more than 90%rates of detection of early-onset preeclampsia. But in combination with biochemical markers increased costs, the future research direction is early screening of optimal combination forecasting model to predict preeclampsia.