外泌体在肝癌发生发展中的研究进展

Progress in research of exosomes in occurrence and development of hepatocellular carcinoma

肝细胞癌(HCC)是最常见的恶性肿瘤之一,死亡率高,预后极差。HCC的发生涉及多种癌基因或抑癌基因的突变,但具体的分子机制尚不清楚。外泌体是细胞外囊泡的一种,可介导细胞间的物质交换和信息交流,近年来发现外泌体在肝癌的发生发展中具有关键作用,可应用于肝癌的诊断与治疗。本文就外泌体的组成与功能及其在肝癌的发生发展、诊断与治疗中的作用作一综述。

Hepatocellular carcinoma（ HCC） is one of the most common tumors worldwide, with a high percentage of mortality as well as extremely poor prognosis. The occurrence of HCC involves a variety of mutations in oncogenes or tumor suppressor genes. However, its specific molecular mechanism is unclear. Exosome is one kind of the extravascular vesicles, which can mediate substance exchange and information communication. Recent studies demonstrate that exosomes contribute to occurrence and development of HCC. Moreover, exosomes can be utilized into the diagnosis and therapy of HCC. This article summarizes the contents and function of exosomes, their effects on occurrence and development, diagnosis and therapy of HCC as well.