沙格列汀治疗老年糖尿病的用药效果评估与研究

Evaluation and Research on Medication Effect of Saxagliptin in Treatment of Senile Diabetes

目的研究沙格列汀治疗老年糖尿病的用药效果。方法随机选择于2014年10月—2015年10月间该院收治的老年糖尿病患者66例,作为该次研究对象,采用电脑随机分组方式,将此次收治于该院的患者随机分为研究组与常规组,各组33例。其中常规组患者给予二甲双胍治疗;研究组患者给予沙格列汀治疗。对比分析两组患者临床治疗总有效率。结果两组患者均进行为期2个月的临床治疗,研究组患者的心肌酶变化情况显著优于常规组,差异有统计学意义(P<0.05),且研究组肝脏、肾脏功能均显著好于常规组,数据对比差异有统计学意义(P<0.05),两组患者并未发现较为严重的药物不良反应(P>0.05)。结论沙格列汀治疗无肝肾功能损伤、轻度或中度老年糖尿病患者,临床疗效十分满意,建议临床应用。

Objective To research the medication effect of saxagliptin in treatment of senile diabetes. Methods 66 cases of senile patients with diabetes admitted and treated in our hospital from October 2014 to October 2015 were randomly select- ed as the research objects and randomly divided into two groups with 33 cases in each, the routine group were treated with melbine, while the research group were treated with saxagliptin, and the total clinical treatment effective rate was compared between the two groups. Results Both groups were treated for two months, and the cardiac enzymes change in the research group was obviously better than that in the routine group, and the difference was obvious （P〈0.05）, and the liver and renal functions in the research group were obviously better than those in the routine group, and the difference had statistical significance （P〈0.05）, and there were no severe drug adverse reactions （P〉0.05）. Conclusion The clinical curative effect of saxagliptin in treatment of senile diabetes is very satisfactory, and it is suggested to be applied in clinic.