基于随访的宫颈癌预后多因素生存分析

Multivariate survival analysis of prognostic factors for cervical cancer based on follow-up

目的调查宫颈癌患者预后生存情况,找出实际医疗环境中影响宫颈癌预后的多种综合因素。方法对纳入研究的病例进行临床资料的收集和随访。采用COX回归模型分别对临床因素、病理因素、自身因素、社会经济因素进行分析。结果共纳入研究对象2 306例,最长随访时间为40个月,中位随访时间为14个月。三年生存率分别为91%、85%、78%。最终纳入COX回归模型的因素有宫旁侵犯程度、脉管癌栓、淋巴结转移、体重减轻、糖尿病史和职业收入。结论临床分期、治疗方案、脉管癌栓等被纳入模型的因素均可能影响宫颈癌患者的预后。

Objective To investigate the living conditions and quality of life of patients with cervical cancer after discharge, and find out the influence of various factors on the prognosis of cervical cancer in the actual medical environment. Methods Clinical data of the patients which were included in the study were collected and followed up. COX regression models were used to analyze the clinical factors, pathological factors, self factors, social and economic fac- tors. Results A total of 2 306 patients was included, the longest follow-up period was 40 months, and the median follow-up was 14 months. The three-year survival rates were 91%, 85% , 78%. Finally, factors included in the COX regression model were parametrial invasion, vascular invasion, lymph node metastasis, weight loss, diabetes and occupation income. Conclusion Clinical stage, treatment options, vascular tumor thrombus and other factors that may affect the prognosis of patients with cervical cancer.