乙肝病毒阳性与阴性原发性肝癌患者的临床特征

Differences in clinical features between hepatitis B virus positive and negative patients with primary liver cancer

目的分析乙型肝炎病毒（HBV）阳性与阴性原发性肝癌（PLC）患者临床特征的差异及其与HBV阳性肝癌TNM分期的相关性。方法回顾性分析2012年1月至2015年12月河南省肿瘤医院肝胆外科手术治疗的430例PLC患者的临床病理资料。按是否有HBV感染进行分组，其中HBV阳性PLC患者362例，HBV阴性68例。采用Х^2检验比较两组患者临床特征的差异，采用Spearman秩相关分析有差异临床特征与HBV阳性肝癌TNM分期的相关性。结果HBV阳性与阴性两组患者性别、年龄分布以及甲胎蛋白（AFP）水平、肿瘤数目、肿瘤大小、病理组织学分型和TNM分期差异均有统计学意义（均P〈0．05）。两组间AFP、肿瘤数目、肿瘤大小、病理组织学分型与TNM分期存在等级正相关关系（均P〈0．05）。结论HBV阳性与HBV阴性PLC患者在性别、年龄分布、AFP水平、肿瘤数目、肿瘤大小、病理组织学分型和TNM分期方面存在显著差异，HBV阳性PLC患者的AFP水平、肿瘤数目、肿瘤大小、病理组织学分型与TNM分期存在等级正相关关系。

Objective To investigate the differences in clinical features between primary liver cancer （PLC） patients with positive and negative hepatitis B virus （HBV） and discuss the correlation of positive HBV and TNM staging. Methods Clinicopathological data of 430 patients with primary liver cancer who underwent partial hepatectomy in Henan Cancer Hospital from November 2012 to December 2015 were retrospectively reviewed. The cases were divided into HBV-positive PLC group （n = 362） and HBV-negative PLC group （n = 68） in according to the HBV infection status. Х^2 test was performed to analyze the clinical feature differences of the two groups. Spearman rank correlation was used to assess the differential clinical features and TNM staging of HBV-positive PLC. Results There were statistic differences in gender, age, AFP level, tumor numbers, tumor size, bistopathological types and TNM staging between two groups （ P 〈 0.05）. Furthermore, AFP level, tumor numbers, tumor size and histopathological types showed positive correlation with TNM staging （all P 〈 0.05）. Conclusions A number of remarked differences in clinical feature of gender, age, AFP level, tumor numbers, tumor size, histopathological types and TNM staging could be observed in HBV-positive PLC patients compared with HBV-negative patients. HBV-positive PLC patients may have positive correlations of AFP level, tumor numbers, tumor size, histopathological types and TNM staging.