荧光激发效应增强切伦科夫光学信号的研究进展

Development of Cerenkov signal enhancement by fluorescence excitation effect

切伦科夫光学成像是光学分子影像学中备受关注的新方法，已成功应用于早期临床试验。信号强度弱、组织穿透力不足是限制其临床应用的瓶颈问题。激发无机、有机材料的切伦科夫光能量转移成像可使光谱向组织穿透能力强的近红外波段移动，激发稀土微粒的放射激发荧光成像可使高能射线激发稀土微粒发出可见及近红外光，从而解决上述问题。笔者对荧光激发效应增强切伦科夫光学信号的研究进展进行综述。

Cerenkov luminescence imaging （CLI） is a new method of optical molecular imaging, which has been successfully applied in early clinical trials. However, weak signal intensity and limited abili- ty in tissue penetration have impeded its clinical application. Cerenkov radiation energy transfer imaging and radiation excitation fluorescence imaging were adopted to solve these problems by enabling transformation of some of the blue-weighted Cerenkov luminescence （CL） spectra to red-shifted emissions, or by exciting rare earth particles to emit visible and near infrared light. This article reviews the development of Cerenkov signal enhancement by fluorescence excitation effect.