中枢神经炎症反应在术后认知功能障碍中作用的研究

Study on the role of central nervous inflammatory reaction in postoperative cognitive dysfunction

术后认知功能障碍(POCD)是术后常见的并发症之一,多见于老年患者。POCD主要表现为患者术后出现的记忆能力下降、注意力不集中等认知功能改变,严重者甚至出现人格改变和(或)社会行为能力下降。目前POCD的发病机制尚不清楚,近年来多数研究认为中枢神经炎症反应在POCD中发挥了重要的作用。本文就POCD发生的主要危险因素、中枢神经炎症反应在POCD中可能的作用机制以及防治措施进行综述。

Postoperative cognitive dysfunction （POCD） is one of the common complications after surgery,which is more common in elderly patients.POCD mainly shows the decline in memory capacity,inattention and other cognitive function changes after the surgery.In severe cases,the patients may show personality changes and/or decline in social-behavior ability.At present,the pathogenesis of POCD has not been clear.In recent years,most studies have suggested that central nervous inflammatory response plays an important role in POCD.Therefore,thfs article will mainly review on the major risk factors of POCD,and potential mechanism of central nervous inflammatory reactions in POCD,as well as prevention and treatment measures.