细针穿刺细胞学检查应用在甲状腺微小乳头状癌诊断中的可行性分析

Feasibility analysis of fine-needle aspiration cytology applied in the diagnosis of papillary thyroid micro-carcinoma

目的探讨超声引导下细针穿刺细胞学检查(US-FNAC)在甲状腺微小乳头状癌(PTMC)诊断中的临床价值。方法回顾性分析2014年3月~2016年10月我院门诊收治的行US-FNAC的95例PTMC患者(124个结节),比较US-FNAC诊断结果与术后病理及临床随访结果。结果 124个结节经US-FNAC诊断显示,恶性、可疑恶性、良性、不典型滤泡性病变、无效标本分别为78、23、13、2、8例;细胞学阴性20例,细胞学阳性104例;术后病理或随访显示,恶性101例,良性23例。US-FNAC诊断PTMC的敏感度为99.01%(100/101),特异度为82.61%(19/23),准确度为95.97%(119/124),阳性似然比5.69,阴性似然比0.01。结论 US-FNAC可应用于PTMC临床诊断中,具有较高的应用价值。

Objective To investigate the clinical value of ultrasound-guided fine-needle aspiration cytology （US-FNAC） in the diagnosis of papillary thyroid micro-carcinoma （PTMC）.Methods The clinical data of 95 patients with PTMC （124 nodules） who underwent US-FNAC in our hospital from March 2014 to October 2016 were retrospectively ana- lyzed.The diagnostic results of US-FNAC were compared with the results of postoperative pathology and clinical fol- low-up.Results US-FNAC showed that the numbers of malignant,suspected malignant,benign,atypical follicular lesions and ineffective specimens were 78,23;13,2 and 8 cases,respectively.There were 20 cases negative in cytology and 104 cases positive.The results of postoperative pathology or follow-up showed that there were 101 malignantcases and 23 benign cases.The sensitivity,specificity,accuracy,positive likelihood ratio and negative likelihood ratio of US-FNAC in the diagnosis of PTMC were 99.01%（100/101）,82.61%（19/23）,95.97%（119/124）,5.69 and 0.01,respectively.Conclusion US-FNAC can be used in the clinical diagnosis of PTMC,whieh has higher application value.