脑心清片对奥氮平所致代谢紊乱的治疗作用

Naoxinqing Pian addition therapy improves olanzapine-induced metabolic disorder

目的观察中药脑心清片对奥氮平治疗精神分裂症所致代谢紊乱的治疗效果。方法本研究共纳入110例住院精神分裂症患者,分为服用奥氮平联合脑心清片(研究组)和奥氮平单药(对照组)各55例,采用自编一般情况调查表、阳性与阴性症状量表(PANSS)及副反应量表(TESS)进行评估。结果治疗前两组患者体质指数、腰围、腰臀比、血糖、总胆固醇、甘油三酯及尿酸比较,差异均无统计学意义(P>0.05)。对照组患者在治疗6周和12周时体质指数、腰围、腰臀比、血糖、总胆固醇及甘油三酯均显著高于研究组,差异有统计学意义(P<0.05);随治疗时间延长,两组患者尿酸水平及与治疗前比较变化不大,差异无统计学意义(P>0.05)。治疗6周和治疗12周,研究组患者PANSS减分程度显著高于对照组,差异有统计学意义(P<0.01);治疗12周时,研究组患者PANSS减分程度仍较大,差异有统计学意义(P<0.05),但对照组患者减分较少,差异无统计学意义(P>0.05)。结论脑心清片可有效预防和减轻奥氮平所致代谢紊乱,且不影响奥氮平疗效。

Objective To observe the treatment effects of naoxinqing pian in preventing olanzapineinduced metabolic disorder. Methods A total of 110 cases of hospitalized schizophrenics were enrolled in this study. 55 cases taking olanzapine plus naoxinqing pian( study group),while the other 55 schizophrenics taking olanzapine alone( control group). Investigated by self-made General Information Questionnaire,Positive and Negative Symptom Scale( PANSS) and Treatment Emergent Symptom Scale( TESS). Results The body mass index( BMI),abdominal perimeter,waist-hip ratio( WHR),blood sugar( GLU),cholesterol( CHOL),triglycerides( TRIG),uric acid( UA) and the total scores of PANSS of two groups had no significant difference before treatment( P>0.05). After 6 weeks and 12 weeks of treatment,the body mass index( BMI),abdominal perimeter,waist-hip ratio( WHR),blood sugar( GLU),cholesterol( CHOL) and triglycerides( TRIG) of control group progressively increased,and significantly higher than study group( P < 0. 05 or P < 0. 01). The comparison of the uric acid( UA) between two groups or ' before-and-after' itself had no significant difference( P>0.05). The total scores of PANSS of two groups reduced obviously in 6 weeks after treatment( P<0.01),and that of study group significantly lower than control group( P < 0. 01); The total scores of PANSS of study group reduced more in 12 weeks after treatment( P<0.05),and significantly lower than control group( P<0.01); But the total scores of PANSS of control group reduced less after 12 weeks of treatment( P > 0. 05). Conclusions Naoxinqing pian could be effective in preventing and reducing olanzapine-induced metabolic disorder,and has no impact on the therapeutic efficacy of olanzapine.