肿瘤标志物TK1在肿瘤患者早期诊断中的临床意义

Clinical significance of tumor marker thymidine kinase 1 in the early diagnosis of cancer patients

目的探讨肿瘤标志物胸苷激酶1(TK1)在肿瘤患者血清中的水平及对肿瘤患者早期诊断的临床价值。方法检测63例肿瘤患者,其中21例肺恶性肿瘤、19例食道恶性肿瘤、23例胃恶性肿瘤和32例健康对照者血清TK1的水平。TK1测定采用免疫印迹法,分析各组肿瘤患者TK1水平并与对照组比较分析。结果各组肿瘤患者血清TK1含量明显高于健康对照组(P<0.05),在各肿瘤组无明显差别(P>0.05)。TK1的诊断敏感度为68.3%,诊断特异度90.6%,诊断符合率为75.8%。结论血清TK1水平对各肿瘤患者早期临床诊断及预后监测有着重要参考价值。

Objective To investigate the concentration of tumor marker thymidine kinase 1( TK1) in the serum and the clinical value in early diagnosis of tumor patients. Methods The serum levels of TK1 were detected in 63 cases of tumor patients,including 21 cases of lung cancer,19 cases of malignant esophagus tumor,23 cases of malignant stomach tumor and 32 cases of healthy control. Western blot analysis was used to analyze the TK1 level of tumor patients in each group and compared with the control group. Results The levels of TK1 in serum of tumor patients in each group were significantly higher than that in healthy control group( P<0.05),and there was no significant difference among the tumor groups( P>0.05). The diagnostic sensitivity of TK1 was 71.7%,the diagnostic specificity was 90.6%,and the diagnostic accordance rate was 75. 8%. Conclusions Serum TK1 level has important reference value for early diagnosis and prognosis of patients with tumor.