认知训练改善卒中后认知功能障碍的系统评价

A Systematic Review of Acupuncture Treatment on Cognitive Impairment after Stroke

目的:系统评价认知训练对卒中后认知功能障碍的疗效。方法:严格按照循证医学系统评价方法,收集所有认知训练对卒中后认知功能障碍的临床随机对照试验研究文献,并对纳入的研究逐个进行质量评价,而后采用Rev Man5.0软件进行Meta分析。结果:7个研究共368例患者符合纳入标准。Meta分析结果显示:PSCI患者的MMSE评分(MD)=5.42,95%CI=(3.16,7.68),差异有统计学意义(P<0.05);BI评分(MD)=11.17,95%CI=(4.40,17.94),差异有统计学意义(P<0.05)。结论:认知训练可有效改善卒中后认知功能障碍患者的认知功能和日常生活能力。

Objective We conducted a meta - analysis to evaluate the efficacy of cognitive training on post - stroke cognitive impairment. Methods Randomized controlled trials （RCTs） comparing cognitive training with no cognitive training in addition to either medicine or rehabilitation were identified from Database. Meta - analyses were conducted for the eligible RCTs. Results Seven trials with a total of 368 patients met inclusion criteria. Pooled random -effects estimates of the change in the Mini -Mental State Examination were calculated for the comparison of cognitive training with no cognitive training in addition to medicine or rehabilitation. Following intervention with cognitive training, the merged mean difference （MD） was 5. 42 （95% CI [ 3. 16, 7. 68 ], P 〈 0. 005 ）. For the comparison of cognitive training with no cognitive training in addition to medicine or rehabilitation groups, the Barthel Index MD was 11.17, 95% CI = （4. 40, 17. 94）, （P 〈 0. 05）. Overall, the study quality was rated as moderate based on the Cochrane Handbook for Systematic Reviews of Intervention ： Part 2 ： 8. 5. Conclusion This metaanalysis suggests that cognitive training had positive effects on cognitive function and Activities of daily living of post - stroke cognitive impairment patient.