MACC1和C-Met在口腔白斑和口腔鳞状细胞癌中的表达及意义

Expression and Significance of MACC-1 and C-Met in the Oral Leukoplakia and Oral Squamous Cell Carcinoma

目的:探讨分析MACC1和C-Met在正常口腔黏膜、口腔白斑及口腔鳞状细胞癌中的表达及其临床意义。方法:采用免疫组化SP法检测20例口腔黏膜、20例上皮异常增生白斑、50例口腔鳞癌组织中的MACC1、C-Met蛋白的表达情况,采用X2和spearman等级相关分析对结果进行判定。结果:MACC1、C-Met蛋白在异常增生型白斑和口腔鳞癌中的阳性表达率分别为50%、76%,35%、66%,均明显高于正常口腔黏膜(17.6%,5.0%),差异均有统计学意义(P<0.05)。MACC1和C-Met蛋白表达与口腔鳞癌的分期、淋巴结转移及分化程度密切相关(P<0.05)。Spearman等级相关分析显示口腔白斑及口腔鳞癌中MACC1和C-Met的表达呈现正相关(P<0.05)。结论:MACC1和C-Met在上皮不典型增生性白斑和口腔鳞癌中高表达,二者在口腔黏膜白斑的癌变和口腔鳞癌的发生发展中可能起重要作用。

Objective： To analyze the expressions of MACC1 and C-Met in normal oral mucosa, oral leukopakia （OLK） and oral squamous cell carcinoma （OSCC） and their clinical significances. Methods： Immunohistochemistry of SP method was ued to detect the expressions of MACC1 and C-Met protein in 20 cases of normal oral mucosa, 20 cases of atypical epithelial proliferative leukoplakia, 50 cases of oral squamous cell carcinoma. Results： The positive expression rates of MACC1 and C-Met in atypical epithelial proliferative leukoplakia and oral squamous cell carcinoma （50%, 76% and 35%,66% respectively） were significantly higherthan those of the normal oral mucosa （17.6%,5.0% respectively） （P〈0.05）. The expression of MACC1 and C-Met protein were associated with the malignant degree, lymph node metastasis and differentiation degree of oral squamous cell carcinoma （P〈0.05）. The results of Spearman analysis showed that MACC1 protein expression in oral squamous cell carcinoma and OLK tissue had positive correlation with C-Met protein expression （P〈0.05）. Conclusion： MACC1 and C-Met were highly expressed in epithelial dysplasia leukoplakia and oral squamous cell carcinoma, and they might play important roles in the carcinogenesis of oral leukoplakia and the occurrence and development of oral squamous cell carcinoma.