痰热清注射液联合纳洛酮对老年慢性呼吸衰竭并发肺性脑病患者临床疗效的影响

Clinical Efficacy of Tanreqing Injection Combined with Naloxone in the treatment of Elderly Patients with Chronic Respiratory Failure and Pulmonary Encephalopathy

目的:探讨痰热清注射液联合纳洛酮对老年慢性呼吸衰竭并发肺性脑病患者临床疗效的影响。方法:选取我院呼吸科收治的慢性呼吸衰竭并发肺性脑病患者60例,随机分为治疗组和对照组,每组30例。对照组给予加痰热清注射液治疗,治疗组在对照组治疗基础上联合纳洛酮注射液治疗。治疗结束后,比较治疗前后两组患者动脉血气分析结果、血清BNP(脑钠肽)、SOD(超氧化物歧化酶)、MDA(丙二醛)水平及临床疗效。结果:与治疗前相比,两组患者治疗后的血清BNP、MDA水平降低,SOD水平升高(P<0.05),PaO_2水平升高,PaCO_2水平下降(P<0.05);与对照组比较,治疗组总有效率较高,BNP、MDA水平较低,SOD水平较高(P<0.05),PaO_2水平较高,PaCO_2水平较低(P<0.05)。结论:痰热清注射液联合纳洛酮治疗老年慢性呼吸衰竭并发肺性脑病临床疗效好,推测其机制与降低血清BNP、MDA及升高血清SOD水平有关。

Objective： To investigate the clinical efficacy of tanreqing injection combined with naloxone in the treatment of elderly patients with chronic respiratory failure and pulmonary encephalopath. Methods： A total of 60 cases with chronic respiratory failure and pulmonary encephalopathy from our hospital were collected and randomly divided into the experiment group and control group with 30 cases in each group. Patients in the control group were treated by tanreqing injection 20ml intravenous drip, 1 time / day; patients in the experiment group were treated on the basis of control group with naloxone injection 2 mg intravenous drip, 1 time/day. Both groups were treated for 4 cycles, a cycle with 7 days. After treatment, the arterial blood gas analysis results, serum BNP and SOD levels before and after the treatment and clinical efficacy were compared between two groups. Results： Compared with before treatment, the serum BNP and MDA levels of both groups were decreased after treatment, the serum SOD levels were increased （P〈0.05）, arterial blood gas analysis results showed PaOz levels were increased, PaCO2 levels were decreased （P〈0.05）; compared with the control group, the total effective rate of experiment group was higher, the serum BNP and MDA levels were lower, the serum SOD levels were higher （P〈0.05）, arterial blood gas analysis results showed the PaO2 levels were higher, PaCO2 level were lower （P〈0.05）. Conclusion： Tanreqing injection combined with naloxone had a good clinical curative effect in the treatment of elderly patients with chronic respiratory failure and pulmonary encephalopathy, which might be related to the decrease of serum BNP and MDA levels, increase of the serum SOD level.