蒙脱石散联合止泻保童颗粒对腹泻患儿血清CRP水平及心肌酶谱的影响

Effect of Montmorillonite Powder Combined with Zhixie Baotong Granula on the Serum CRP and Myocardial Enzyme Spectrum Level in Children with Diarrhea

目的:研究蒙脱石散联合止泻保童颗粒对腹泻患儿血清C反应蛋白(CRP)及心肌酶谱水平的影响。方法:回顾性分析2012年7月至2013年6月在本院进行治疗的腹泻患儿,39例采取蒙脱石散治疗(对照组),39例采取蒙脱石散联合止泻保童颗粒治疗(观察组)。比较两组患儿有关症状改善时间和临床疗效,分析两组患儿治疗前后血清CRP及心肌酶谱水平。结果:治疗后,观察组总有效率显著高于对照组(P<0.05),血清CRP、谷丙转氨酶(ALT)、乳酸脱氢酶(LDH)、肌酸激酶(CK)、谷草转氨酶(AST)、肌酸激酶同工酶(CK-MB)水平均显著低于对照组(P<0.05),止泻时间、大便恢复至正常时间、退热时间显著短于对照组(P<0.05)。结论:腹泻患儿经蒙脱石散联合止泻保童颗粒治疗较单用蒙脱石散能更有效降低患儿血清CRP水平,改善患儿的心肌酶谱水平,患儿的临床症状可快速恢复,临床疗效更好。

Objective： To study the effect of montmorillonite powder combined with Zhixie Baotong granula on the serum CRP and myocardial enzyme spectrum level in children with diarrhea. Methods： The clinical data of patients with diarrhea treated from July 2012 to June 2013 were retrospectively analyzed, 39 cases underwent montmorillonite powder （control group）, and 39 cases were treated with montmorillonite powder combined with Zhixie Baotong granula （observation group）. The symptoms improve time and clinical curative effect between two groups were compared, the serum CRP and myocardial enzyme levels before and after treatment serum between two groups were analyzed. Results： After treatment, the total effectiveness of observation group was significantly higher than that of the control group （P〈0.05）. the serum CRP, alanine aminotransferase （ALT）, lactate dehydrogenase （LDH）, creatine kinase （CK）, aspertate aminotransferase （AST）, creatine kinase isoenzyme （CK-MB） levels were significantly lower than those of the control group （P〈0.05）, the antidiarrheal time, shit back to normal time, antifebrile time were significantly shorter than those of the control group. Conclusion： Montmorillonite powder combined with Zhixie Baotong Granula could more effectively reduce the serum CRP level, improve the myocardial enzyme spectrum, clinical symptoms and had better clinical curative effect than montmorillonite alone in the treatment of children with diarrhea.