木贼配方颗粒质量标准研究

Study on Quality Standard of MuZei Dispensing Granules

目的:建立木贼配方颗粒质量标准。方法:采用TLC法对木贼配方颗粒进行鉴别;采用HPLC法对木贼配方颗粒中的山奈素进行测定,并对木贼配方颗粒相关指标进行检查。结果:TLC方法中木贼配方颗粒在与木贼对照药材对应位置上,呈现相同颜色的斑点;山奈素的线性范围为0.040 48~0.404 8μg(r=0.999 8),平均回收率为98.44%(RSD=1.21%,n=9)。木贼配方颗粒水分、溶化性、粒度均达到药典颗粒剂的要求。结论:该方法简便、准确、重复性好,可用于木贼配方颗粒的质量控制。

Objective：To establish the quality standard of MuZei （Equisetum hiemale） dispensing granules. Methods：MuZei dispensing granules were discerned by TLC method;at the same time, the kaempferide from MuZei dispensing granules was measured by HPLC method, and the relevant indexes of MuZei dispensing granules were examined. Results：MuZei dispensing granules in TLC showed the same color spots at a position corresponding to the control medicine of MuZei; The linear range of kaempferol was 0.04048~0.4048 μg （r=0.9998）, and the average recovery rate was 98.44% （RSD=1.21%, n=9）. The moisture, solubility, and particle size of MuZei dispensing granules all reached the requirements of Pharmacopoeia granules. Conclusion： This method is simple, accurate, reproducible, and can be used for quality control of MuZei dispensing granules.