血液肿瘤患儿合并侵袭性真菌感染研究进展

Invasive fungal diseases in children with hematologic malignancies

侵袭性真菌病（invasive fungal disease，IFD）已经成为血液肿瘤患儿致病和致死的重要原因。虽然白假丝酵母菌仍是目前儿童侵袭性真菌感染中最常见的致病真菌，但近年来非白假丝酵母菌所致感染和侵袭性曲霉菌感染有显著上升。早期治疗和及时的抗真菌治疗是控制IFD的关键。该文对血液肿瘤患儿合并IFD的诊断及治疗进行综述，以期为临床医生提供帮助。

Invasive fungal diseases （IFD） are important causes of morbidity and mortality in children with hematological malignancies. Although Candida remains the most common fungal pathogen in ontology patients, the epidemiology has recently shifted toward non-albicans species. However, Aspergillus has also seen a recent rise. Early recognition and prompt antifungal treatment are key to the control of IFD. We provide clinicians with evidence-based recommendations on strategies for disease diagnosis and management in this review.