P-物质、血管活性肠肽、胃泌素和5-羟色胺与胃肠功能的研究进展

Substance P, vasoactive intestinal peptide, gastrin, 5-hydroxytryptamine and gastrointestinal function

P-物质、血管活性肽和胃泌素属于胃肠激素；5-羟色胺（5-HT）属于神经递质。P-物质和血管活性肽是广泛存在肠黏膜中的神经肽，在肠道运动和分泌方面发挥着重要作用。胃泌素是第一个被阐明结构的胃肠激素，可以促进胃肠运动，破坏自发和胃动素所致的移行性运动复合波，使空腹样胃肠运动转变为餐后样运动。5-HT是血管活性胺类物质，通过5-HT受体调控血管壁的通透性。该文从P-物质、血管活性肠肽、胃泌素和5-HT的来源、分布及在胃肠功能中的研究进展作一综述。

Substance P,vasoactive intestinal peptide and gastdn belong to the gastrointestinal hormone; 5-hydroxyptamine（5-HT） is a neurotransmitter. Substance P and vasoactive intestinal peptide are widely present in the intestinal mucosa and play an important role in the intestinal motility and secretion. As the first gastro-intestinal hormone whose molectflar structure has been clarified, gastrin can promote gastrointestinal motility, for sports complex displacement damage caused by spontaneous and motilin, make the gastrointestinal movement into postprandial fasting like movement. 5-HT belongs to vasoactive amines, regulates the permeability of the blood vessel wall through 5-HT receptors. In this review, the origin, distribution and progress in gastrointestinal function of vasoactive intestinal peptide, gastrin and 5-hydroxytryptamine will be summarized.