炎性细胞因子与新生儿胆红素脑损伤的研究进展

Research progress of inflammatory cytokines and neonatal bilrubin brain damage

近年来，新生儿高未结合胆红素脑损伤过程中的炎症反应引起了越来越多学者的关注。研究表明，炎症反应在新生儿胆红素脑损伤发生、转归中起着重要的作用。大量的非结合胆红素透过血脑屏障，促使神经胶质细胞活化，产生免疫应答，释放炎性细胞因子，引起神经细胞的凋亡、坏死及损伤修复。该文就炎性细胞因子（肿瘤坏死因子-α、白细胞介素石、8、1β、10等）在新生儿胆红素脑损伤发生及保护中的作用机制进行综述。

In recent years,more and more attention has been paid to the inflammatory reaction in the process of neonatal unconjugated bilirubin brain damage. Studies have shown that inflammation plays an important role in the occurrence and prognosis of neonatal b＇dirubin brain injury. A large amount of unconjugated bilirobin pass through the blood brain barrier, causing glial cells activation, emerging immune response, releasing inflammatory cytokines, leading the apoptosis, necrosis and damage repair of neuronal. This article reviews the occurrence and protection mechanism of inflammatory cytokines（ tumor necrosis factor-a, interleukin-6,8,113,10, et. al）in neonatal bilirubin brain damage.