肾小管上皮间质转化的研究进展

Research progress of renal tubular epithelial-to-mesenchymal transition

肾间质纤维化（renal interstitial fibrosis，RIF）是所有慢性肾脏病发展为终末期肾病的共同通路。RIF的发病机制复杂，目前尚不完全清楚。研究发现肾小管上皮间质转化（epithelial-to-mesenchymal transition，EMT）在RIF的发病机制中起重要作用。抑制或逆转肾小管EMT有助于延缓RIF的发生及发展。该文主要对肾小管EMT的发生机制及药物治疗的研究概况作一综述。

Renal interstitial fibrosis represents the final common pathway of all chronic disease. The mechanism of renal interstitial fibrosis is very complex. It is not entirely clear now. The study found that epithelial-to-mesenchymal transition plays an important role in the renal interstitial fibrosis. Inhibition of epithelial-to- mesenchymal transition may help to slow down the development and progression of renal interstitial fibrosis. The article mainly reviews the mechanism and treatment of enithelial-to- mesenchymal transition.