半胱氨酸组织蛋白酶对牙本质粘接耐久性的影响

Influence of cysteine cathepsins on dentin bonding durability

半胱氨酸组织蛋白酶是组织蛋白酶家族的主要成员。牙本质酸蚀脱矿后裸露的胶原纤维被内源性蛋白酶降解是影响牙本质粘接耐久性的主要因素之一。除基质金属蛋白酶外,半胱氨酸组织蛋白酶也在粘接过程中被激活并参与混合层中胶原的破坏。本文就半胱氨酸组织蛋白酶与基质金属蛋白酶的相互作用、在牙本质粘接中的作用以及半胱氨酸组织蛋白酶抑制剂对提高牙本质粘接耐久性的作用的研究进展作一综述。

Cysteine cathepsins are the major members of cathepsins. Exposed collagen is produced by demineralization during the process of dentin bonding. The degradation of the exposed collagen by endogenous proteases is one of the main factors that affect dentin bond durability. In addition to matrix metalloproteinases（MMPs）, which play an important role in the decrease of dentin bonding durability, cysteine cathepsins are activated during the bonding process and then participate in the destruction of collagen in the hybrid layer. This study clarifies the interaction between cysteine cathepsins and MMPs and the influence ofcysteine cathepsinson dentin bonding and reviews the research progress of the application of cysteine cathepsins inhibitor in improving dentin bonding durability.