高血压患者血清血小板衍生生长因子-B与颈动脉IMT的相关性

Correlation between the Serum Levels of Platelet-Derived Growth Factor-BB and Carotid Artery Intima-media Thickness in Patients with Essential Hypertension

目的探讨高血压患者的血清血小板衍生生长因子-B与颈动脉内膜中层厚度的相关关系.方法将未受药物影响、且未合并其他疾病的原发性高血压患者90例进行颈动脉内膜中层厚度检测及血清血小板衍生生长因子-B检测(ELISA法),并进行相关性分析.结果本组90例患者收缩压为(150.16±9.18)mm Hg,舒张压为(99.92±6.32)mm Hg;颈动脉IMT为(0.78±0.43)mm,血清PDGF-BB为(25.78±12.76)ng/m L.颈动脉内膜中层厚度与血清血小板衍生生长因子-B呈中度正相关关系(r=0.483,P=0.000,P<0.001).结论高血压患者血清血小板衍生生长因子-B与颈动脉内膜中层厚度呈中度正相关关系相关性.

Objective To study the correlation between the serum levels of platelet-derived growth faetor-BB and carotid artery intima-media thickness in patients with essential hypertension. Methods Ninety essential hypertension patients without medication intake and other diseases were examined or blood and carotid artery color Doppler ultrasonogra. The serum levels of PDGF-BB were measured using ELISA. Carotid artery intima-media thickness was measured using color Doppler ultrasonogra. And, they was analyzed by linear correlation. Results The systolic blood pressure was 150.16 ± 9.18 mmHg, diastolic blood pressure was 99.92 ± 6.32 mmHg, carotid artery color Doppler uhrasonogra was 0.78 ± 0.43 ram, The serum levels of PDGF-BB was 25.78 ± 12.76 ng/mL. The serum level of PDGF-BB was moderately positively correlated with carotid artery intima-media thickness （r =0.483, P=0.000, P〈0.001）. Conclusion The serum level of PDGF-BB is moderately positively correlated with carotid artery intima-media thickness in patients with essential hypertension.