乳果糖联合双歧杆菌三联活菌胶囊治疗轻微型肝性脑病临床效果分析

Analysis of clinical effect of lactulose combined with Bifid triple viable capsule for treatment of mild hepatic encephalopathy

目的探讨乳果糖联合双歧杆菌三联活菌胶囊治疗轻微型肝性脑病(MHE)的临床效果。方法选择我院收治的MHE患者80例,随机分成两组,各40例。对照组给予传统保肝治疗,观察组在对照组治疗的基础上采用乳果糖联合双歧杆菌三联活菌胶囊治疗,比较两组患者治疗前后的数字连接实验(NCT)、数字符号实验(DST)、血氨的水平以及不良反应发生率。结果观察组治疗效果高于对照组(P<0.01)。治疗后两组患者血氨水平均明显下降(P<0.01);观察组患者下降幅度大于对照组(P<0.05)。治疗后两组患者智力测验结果均有改善(P<0.05);治疗后两组比较,NCT-A、NCT-B差异不显著,观察组患者DST低于对照组(P<0.01)。观察组患者不良反应发生率低于对照组(P<0.05)。结论乳果糖联合双歧杆菌三联活菌胶囊治疗MHE有很好的治疗效果,可有效改善血氨水平及智力测验水平,降低不良反应发生率,改善预后。

Objective To discuss into the clinical effects of lactulose combined with Bifid triple viable capsule in the treatment of mild hepatic encephalopathy. Methods Eighty patients with mild hepatic encephalopathy admitted to treated our hospital were selected, and the patients were randomly divided into observation group and control group, with 40 cases in each group. The control group was given the traditional treatment of heptoprotection, while the observation group, on the basis of treatment of the control group, was treated with lactulose combined with Bifidobacterium triple viable capsules, and digital connectivity test （NCT）, digit symbol test （DST）, blood ammonia level and incidence of adverse reactions before and after treatment were compared between the two groups. Results The observation group showed better results （ P 〈 0. 01 ） ; After treatment, blood ammonia levels of the two group dropped and, blood ammonia level in the observation group was lower than that of the control group （ P 〈 0. 05 ） ; results of the intellgence test improved in both groups（P 〈0. 05） and NCT-A and of NCT-B of both groups showed no significant difference,but DST of the observation group was lower than that of the control group ;The incidence rate of adverse reactions in the observation group was lower than that in the control group （ P 〈 0. 05 ）. Conclusion The lactulose combined with Bifid triple viable capsule has good treatment effect in the treatment of mild hepatic encephalopathy, which can effectively improve the level of blood ammonia and intelligence test, reduce the incidence rate of adverse reactions,improve the prognosis and is clinically applicable.