红细胞分布宽度与冠心病患者冠状动脉血流储备分数的相关性研究

Correlation between Red Cell Distribution Width and Coronary Fractional Flow Reserve of Patients with Coronary Heart Disease

目的分析红细胞分布宽度(RDW)与冠心病患者冠状动脉血流储备分数(FFR)的相关性。方法选取2014年6月—2016年6月在湖北医药学院附属随州医院心内科住院并行冠状动脉造影检查的冠心病患者360例,根据FFR分为FFR≥0.80者150例(A组)、0.75≤FFR<0.80者60例(B组)及FFR<0.75者150例(C组)。比较3组患者一般资料和血生化检查指标,冠心病患者FFR的影响因素分析采用多因素Logistic回归分析,相关因素分析采用多元线性回归分析。结果 3组患者年龄、男性比例、体质指数、饮酒率及血肌酐、总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇水平比较,差异无统计学意义(P>0.05);3组患者吸烟率、糖尿病发生率、收缩压、舒张压、超敏C反应蛋白(hs-CRP)水平及RDW比较,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,吸烟[OR=3.449,95%CI(1.221,6.534)]、糖尿病[OR=9.689,95%CI(4.212,22.287)]、收缩压[OR=1.334,95%CI(1.016,1.912)]、舒张压[OR=1.726,95%CI(1.110,2.762)]、hs-CRP[OR=2.413,95%CI(1.223,4.808)]、RDW[OR=1.231,95%CI(1.053,1.918)]是冠心病患者FFR的影响因素(P<0.05)。多元线性回归分析结果显示,hs-CRP(回归系数=-0.14)和RDW(回归系数=-0.16)与冠心病患者FFR独立相关(P<0.05)。结论 RDW与冠心病患者FFR独立相关,RDW增高是冠心病患者FFR降低的独立影响因素。

Objective To analyze the correlation between red cell distribution width （RDW） and coronary fractional flow reserve （FFR） of patients with coronary heart disease （CHD）. Methods From June 2014 to June 2016, a total of 360 CHD inpatients undergoing coronary angiography examination were selected in the Department of Cardiovascular Medicine, Suizhou Hospital Affiliated to Hubei Medical College, and they were divided into A group （with FFR equal or over 0. 80, n =150）, Bgroup （with FFR equal or over0.75 but less than 0.80, n=60） and C group （with FFR less than 0.75, n = 150）. General information and blood biochemical parameters were compared among the three groups, multivariate logistic analysis was used to analyze the influencing factors of FFR of patients with CHD, and multivariate linear regression analysis was used to analyze the related factors of FFR of patients with CHD. Results No statistically significant differences of age, proportion of male, BMI, drinking rate, Scr, TC, TG, HDL-C or LDL-C was tound between the two groups among the threegroups （P 〉0. 05）, while there were statistically significant differences of smoking rate, incidence of diabetes, SBP, DBP, hs-CRP and RDW （P 〈0. 05）. Multivariate Logistic regression analysis results showed that, smoking [ OR = 3. 449, 95% CI （1.221, 6.534）], diabetes [OR=9.689, 95%CI （4.212, 22.287）], SBP [OR=1.334, 95%CI （1.016, 1.912）], DBP [OR = 1.726, 95% CI （1. 110, 2. 762）], hs-CRP [OR = 2. 413, 95% CI （1.223, 4. 808）] and RDW [OR = 1. 231, 95% （3 （ 1. 053, 1. 918） ] were influencing factors of FFR of patients with CHD （P 〈 0. 05 ）. Multivariate linear regression analysis results showed that, hs-CRP （β = -0. 14） and RDW （β = -0. 16） was independently correlated with FFR of patients with CHD, respectively （P 〈0. 05）. Conclusion RDW is respectively correlated with FFR of patients with CHD, elevation of RDW is one of influencing factors of decrease of FFR.