注射用血栓通治疗急性心肌梗死的临床疗效及其对心功能的影响

Clinical Effect of Xueshuantong for Injection on Acute Myocardial Infarction and the Impact on Cardiac Function

目的观察注射用血栓通治疗急性心肌梗死(AMI)的临床疗效,探讨其对心功能的影响。方法选取2012年9月—2016年10月眉山市人民医院收治的AMI患者80例,采用随机数字表法分为试验组与对照组,每组40例。对照组患者予以常规治疗,试验组患者在对照组基础上予以注射用血栓通治疗;两组患者均持续治疗1周。比较两组患者临床疗效,治疗前后血清肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白Ⅰ(cTnⅠ)、内皮素1(ET-1)、超氧化物歧化酶(SOD)水平,治疗前、治疗后1个月心功能指标[左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)],并记录两组患者心脏不良事件发生情况。结果试验组患者临床疗效优于对照组(P<0.05)。治疗前两组患者血清CK-MB、cTnⅠ、ET-1、SOD水平比较,差异无统计学意义(P>0.05);治疗后试验组患者血清CK-MB、cTnⅠ、ET-1水平低于对照组,血清SOD水平高于对照组(P<0.05)。治疗前两组患者LVEDD、LVEF比较,差异无统计学意义(P>0.05);治疗后1个月试验组患者LVEDD短于对照组,LVEF高于对照组(P<0.05)。试验组患者心脏不良事件发生率低于对照组(P<0.05)。结论注射用血栓通治疗AMI的临床疗效确切,可有效减轻患者心肌损伤并改善患者心功能,溶解血栓,防止心肌再灌注损伤,减少心脏不良事件的发生。

Objective To observe the clinical effeut of xueshuantong for injection on acute myocardial infarction, to explore the impact on cardiac function. Methods A total of 80 patients with acute myocardial infarction were selected in the People＇s Hospital of Meishan from September 2012 to October 2016, and they were＇divided into control group and test group according to random number table, each of 40 cases. Patients of control group received conventional treatment, while patients of test group received extra xueshuantong for injection based on conventional treatment; both groups continuously treated for 1 week. Clinical effect, serum levels of CK-MB, cTnI, ET-1 and SOD before and after treatment, and index of cardiac function （including LVEDD and LVEF） before treatment and after 1 month of treatment were compared between the two groups, meanwhile incidence of adverse cardiovascular events was recorded. Results The clinical effect of test group was statistically significantly better than that of control group （ P 〈 0.05 ）. No statistically significant differences of serum level of CK-MB, cTnl, ET-1 or SOD was found between the two groups before treatment （ P 〉 0：05 ） ; after treatment, serum levels of CK-MB, cTnl and ET-1 of test group were statistically significantly lower than those of control group, while serum SOD level of test group was statistically significantly higher than that of control group （ P 〈 0. 05 ）. No statistically significant differences of LVEDD or LVEF was found between the two groups before treatment （ P 〉 0. 05 ） ; after 1 month of treatment, LVEDD of test group was statistically significantly shorter than that of control group, while LVEF of test group was statistically significantly higher than that of control group （ P 〈 0. 05 ）. Incidence of adverse cardiovascular events of test group was statistically significantly lower thanthat of control group （P 〈 0. 05 ）. Conclusion Xueshuantong for injection has certain clinical effect in treating patients with acute myocardial infarction, can effectively reliere the myocardial damage and improve the eardiac function, dissolve the thrombus, prevent the myocardial reperfusion damage and reduce the risk of adverse cardiovascular events.