摘要
目的观察雄芍汤对肝纤维化大鼠转化生长因子-β1(TGF-β1)和结缔组织生长因子(CTGF)的影响。方法采用DMN诱导制备肝纤维化大鼠模型,正常对照组注射等剂量生理盐水,将wistar大鼠随机分为4组,正常对照组:正常喂养;模型对照组:DMN诱导成模后,自然恢复;扶正治疗组:DMN诱导成模后,灌胃扶正化瘀胶囊(0.525g·kg^(-1));雄芍治疗组:DMN诱导成模后,灌胃雄芍汤(8.050g·kg^(-1))。结果雄芍治疗组肝纤维化程度及CTGF、TGF-β1表达均显著低于模型组(P<0.01)。结论雄芍汤有促进DMN诱导肝纤维化大鼠恢复的作用,其机制可能与抑制其TGF-β1和CTGF表达有关。
Objective To observe the effect of Xiongshao Decoction on liver fibrosis in rat transformation growth factor beta 1（TGF-β1） and connective tissue growth factor（CTGF）.Methods The DMN induced and prepared the rat model of liver fibrosis,Wistar rats were randomly divided into 4 groups,blank control group：normal feeding;the model control group：the DMN induced model,the natural recovery;Fuzheng treatment group：DMN induced model,and feeding Fuzheng Huayu Capsule（0.525g·kg^（-1））;Xiongshao treatment group：the DMN induced into mould,and feeding Xiongshao Decoction（8.050g·kg^（-1））.Results Expression of CTGF and TGF-β1were significantly lower in the Xiongshao treatment group than in the model group（P0.01）.Conclusion Xiongshao decoction has promote DMN induced liver fibrosis rats recovery,the mechanism may be related to the inhibition of expression of the TGF-β1 and CTGF.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2017年第3期585-587,共3页
Lishizhen Medicine and Materia Medica Research
基金
山西门氏杂病传承工作室建设项目
