内质网应激与缺血性脑损伤的关系及中医药研究近况

Relationship of endoplasmic reticulum stress and ischemic brain injury and research progress in TCM

内质网是真核细胞内蛋白质折叠、组装的场所。一旦细胞内稳态遭到破坏,大量未折叠或错误折叠的蛋白就会在内质网中堆积,影响内质网的正常生理功能,引发内质网应激(endoplasmic reticulum stress,ERS)反应。研究发现,ERS可能是缺血性脑损伤后造成急性局部缺血、神经元损失的重要原因,但由于其中机制复杂,目前尚未十分明确。中医药在本病的康复治疗中拥有独特的优势。文章主要介绍近年来中医药在ERS与缺血性脑损伤关系中的研究概况。

Endoplasmic reticulum is the place where protein is folded and assembled in eukaryotic cells.Once the cell homeostasis is destroyed,the accumulation of a large number of unfolded or misfolded proteins in the cells will influence the normal physiological function of endoplasmic reticulum,causing endoplasmic reticulum stress reaction（ERS）.Studies have found that ERS may be an important cause of ischemic brain injury after acute ischemia and neuronal loss.However,due to the complex mechanism which remains unclear.The traditional Chinese medicine has an unique advantage in the treatment of this disease.This article reviews the traditional Chinese medicine recent development of ERS and ischemic brain injury.