DLX2在结肠癌中的表达及其临床意义

Expression and clinical significance of distal-less homeobox 2 in colon cancer

目的探讨DLX2在结肠癌组织及癌旁正常组织中的表达差异及在结肠癌中的意义。方法收集96例结肠癌患者的癌组织及相应癌旁正常组织,应用免疫组织化学技术检测DLX2的表达,分析其表达与结肠癌临床病理参数的关系。结果结肠癌组织中DLX2呈阳性表达,与癌旁正常组织相比,其表达水平显著升高(P<0.01)。DLX2的表达在结肠癌的不同TNM分期、不同分化程度和是否有淋巴结转移之间,差异均有统计学意义(P<0.05)。结论 DLX2的高表达可能促进结肠癌的发生发展,深入研究其功能有可能为结肠癌的诊断治疗及预后提供新的靶标。

Objective To investigate the expression and clinical significance of Distal-less homeobox 2 （ DLX2 ） protein in colon canc- er. Methods Immunohistochemistry was used to detect the expression of DIX2 protein in 96 colon cancer tissues and adjacent non- tumor tissues. Statistical analysis was used to evaluate the relationship between the clinicopathological parameters and the expression of DLX2. Results The DLX2 expression was significantly higher in colon cancer tissues than that of the corresponding non-tumor tis- sues（P 〈 0. 01 ）. The up-regulation of DLX2 was significantly related with TNM stage, differentiation grade and lymph node metastasis （P 〈 0. 05）. Conclusion The results suggest that higher expression of DLX2 may promote the carcinogenesis and progression of colon cancer. Further study on the function of DLX2 may provide a new strategy for the diagnosis, treatment and prognosis of colon cancer.