吸附亚甲基蓝的纳米金/凹凸棒土复合抗菌剂的制备及其在PMMA中的应用

Preparation of Au nanoparticles/attapulgite antibacterial agent adsorbed methylene blue and its application in PMMA material

以凹凸棒土为载体,通过硼氢化钠还原氯金酸的方法得到粒径可控,分布均匀的纳米金/凹凸棒土(Au-OAT),将亚甲基蓝吸附于Au-OAT上制得MB-Au-OAT抗菌剂。将MB-Au-OAT添加到甲基丙烯酸甲酯(MMA)单体中,采用原位聚合法制备出聚甲基丙烯酸甲酯(PMMA)复合材料。结果表明,MB-Au-OAT在光照下的最小抑菌浓度(MIC)为0.06mg/mL,黑暗中的最小抑菌浓度为0.08mg/mL,与Au-OAT相比,抗菌活性明显增强。当MB-Au-OAT添加量为3%时,PMMA复合材料综合力学性能最佳,在光照及黑暗条件下对大肠杆菌的抗菌率均达到100%。

Using attapulgite as a carrier,Au/attapulgite （Au-OAT） was prepared by the method of reducing chloro- auric acid with sodium borohydride, and Au nanoparticles had narrow size distribution with controllable size. Methylene blue was adsorbed on the Au-OAT to obtain MB-Au-OAT antibacterial agent. MB-Au-OAT was added into methyl methacrylate （MMA） monomer to prepare PMMA composite by in situ polymerization method. The results showed that under light and dark conditions, the minimal inhibitory concentration （MIC） of MB-Au-OAT antibacterial agent were 0.06mg/mL and 0.08mg/mL respectively,which were much less than the MIC of Au-OAT. When the content of MB-Au-OAT was 3%, PMMA composite showed excellent comprehensive mechanical properties, and its antibacterial rates to E. coli were both reached 100% under light and dark conditions.