甲功异常母亲对婴幼儿甲功的影响,早期干预治疗对其智力障碍的补偿作用

Influence of abnormal mother on infant thyroid function, early intervention treatment on the compensation for mental retardation

目的观察甲亢和甲减病人合并妊娠生产后,婴儿的甲功变化,智力异常,和早期干预治疗后对婴幼儿智力障碍的补偿作用。方法对2010-2016年在吉林市中心医院妇产科、内分泌科就诊的甲功异常的妊娠妇女,共151名,孕妇在G12和G24分别测FT3、FT4、TSH、TPO、TG-ab。婴儿在出生时,6个月,12个月,分别检查甲功五项和运动、智力评分。结果甲亢组和甲减组妊娠妇女经干预治疗G12和G24时,甲功趋于正常,FT_3、FT_4、TSH水平无明显差异。甲亢组婴儿出生时TSH明显升高,其水平与其他两组比较P<0.05,差异有统计学意义,各组孕妇后代神经智力发育及运动评分的比较MDI和PDI,甲亢组MDI和PDI水平有所下降,但后期上升明显,各组有所差别,但无统计学意义。我们早期干涉后婴儿的甲功和神经智力发育及运动评分明显上升,与健康对照组无显著差异。结论孕母甲功异常可以影响子代的甲状腺功能,使子代的智能发育受影响。甲亢组不良妊娠明显增多,孕妇甲功异常的及时干预治疗,子代甲功的及时调整,可以子代的智力评分和运动评分绝对值上升,对其子代的智力障碍有补偿作用。

Objective To observe the hyperthyroidism and hypothyroidism patients with pregnancy after production, the baby＇s thyroid function changes, the baby＇s mental abnormality, compensation for the children with intellectual disabilities and early intervention after treatment.Methods In this study, 151 pregnant women with abnormal thyroid function from Department of Endocrinology in Jilin Central Hospital between 2010- 2016, these women in the G12 and G24 were measured FT_3, FT_4, TSH,TPO, TG-ab, the babies at birth, 6 months, 12 months, examine their thyroid function, exercise and intelligence score respectively.Results Hyperthyroidism group and hypothyroidism group of pregnant women after intervention treatment of G12 and G24,thyroid function tends to be normal, there were no significant differences in FT_3, FT_4 and TSH levels. TSH was significantly increased in the patients with hyperthyroidism group at birth, compared with the other two groups, P〈0.05, the difference was statistically significant.Comparison of the nerve intelligence development and motor scores of the pregnant women in each group MDI and PDI, the levels of MDI and PDI in the hyperthyroidism group were decreased, but the late rise was obvious, there was no significant difference between the groups. There was no significant difference in the development of thyroid and nerve intelligence and motor scores after early intervention in the healthy control group. Conclusion The abnormal thyroid function of pregnant women can affect the thyroid function of offspring,so that the intelligence development of offspring is affected.Adverse pregnancy was significantly increased,timely intervention treatment of pregnant women with abnormal thyroid function and adjustment of sub generation,the intelligence score and the absolute value of the motor score can be increased,it shows compensative effect on mental retardation in their offspring.