中性粒细胞-淋巴细胞比率与老年NSCLC患者临床病理及预后的相关性分析

Correlative Analysis of Neutrophil/lymphocyte Ratio with the Clinicopathology and Prognosis of Elderly Patients with Non-small Cell Lung Cancer

目的:研究中性粒细胞-淋巴细胞比率(NLR)与老年非小细胞肺癌(NSCLC)患者临床病理及预后的相关性分析。方法:回顾性分析我院收治的68例老年NSCLC患者的临床病理资料。根据化疗前NLR分为低NLR组(<2.95)、高NLR组(≥2.95)。比较两组患者临床病理特点及无病生存期(DFS),并分析预后的影响因素。结果:与低NLR组比较,高NLR组临床分期Ⅳ期、吸烟及淋巴转移的比例更大(P<0.05),而两组间年龄、性别、病理类型及合并症比较差异均无统计学意义(P>0.05)。低NLR组中位DFS为7.2个月(95%CI:5.9~8.4),显著高于高NLR组中位DFS 6.7个月(95%CI:5.4~7.9)(P<0.05)。淋巴转移、NLR是老年NSCLC患者DFS的独立危险因素,而年龄、化疗次数则是独立保护因素(P<0.05)。结论:NLR与老年NSCLC患者的临床分期和淋巴结转移有明显相关性,并可作为预后评估参考指标之一。

Objective： To explore the correlation ofneutrophil/lymphocyte ratio （NLR） with the clinicopathology and prognosis of elderly patients with non-small cell lung cancer （ARDS）. Methods： The clinical data of 68 cases of elderly patients with NSCLC in our hospital were retrospectively analyzed. According to the NLR before chemotherapy, patients were divided into the low NLR（〈2.95）group and the high NLR （≥ 2.95）group. The clinicopathological characteristics and disease-free survival （DFS） were compared between two groups, and the influencing factors of prognosis were analyzed. Results： Compared with low NLR group, higher proportion of clinical stage IV, smoking and lymph node metastases were observed in high NLR group （P〈0.05）, while no statistically significant difference was found in the age, sex, pathological types and complications between two groups （P〉0.05）. The median DFS in low NLR group was 7.2 months （95% CI： 5.9-8.4）, which was significantly longer than 6.7 months （95% CI： 5.4-7.9） in high NLR group （P〈0.05）. Lymph node metastases and NLR were the independent risk factors of DFS in elderly patients with NSCLC, while age, number of chemotherapy were independent protection factors （P〈0.05）. Conclusions： NLR was obviously correlated with the clinical stage and lymph node metastases of elderly patients with NSCLC, it could also be used as evaluation index of prognosis.